AOP-Wiki

API

All KERs

Showing 376 to 400 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2444	1907: ASL Height, Decreased	1910: Mucus Viscosity, Increased	Jul 19, 2021	Aug 2, 2021	None
23	97: Alkylation, DNA	336: Increase, Heritable mutations in offspring	Nov 29, 2016	Nov 29, 2016	1 AOP 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
24	97: Alkylation, DNA	155: Inadequate DNA repair	Nov 29, 2016	Dec 10, 2019	3 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 139: Alkylation of DNA leading to cancer 1 322: Alkylation of DNA leading to reduced sperm count
25	97: Alkylation, DNA	185: Increase, Mutations	Nov 29, 2016	Nov 29, 2016	2 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 139: Alkylation of DNA leading to cancer 1
901	97: Alkylation, DNA	885: Increase, Cancer	Nov 29, 2016	Dec 3, 2016	1 AOP 139: Alkylation of DNA leading to cancer 1
269	244: Alkylation, Protein	55: Cell injury/death	Nov 29, 2016	Nov 29, 2016	1 AOP 38: Protein Alkylation leading to Liver Fibrosis
271	244: Alkylation, Protein	209: Peptide Oxidation	Nov 29, 2016	Dec 3, 2016	None
3135	244: Alkylation, Protein	177: Mitochondrial dysfunction	Feb 28, 2024	Feb 28, 2024	1 AOP 258: Renal protein alkylation leading to kidney toxicity
3094	1060: Alteration, lipid metabolism	1513: General Apoptosis	Oct 18, 2023	Oct 19, 2023	1 AOP 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
338	310: Alteration, Wnt pathway	240: Feminisation or incomplete development, Primary and accessory male sex organs	Nov 29, 2016	Dec 3, 2016	1 AOP 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
997	854: Alterations, Cellular proliferation / hyperplasia	856: Formation, Hepatocellular and Bile duct tumors	Nov 29, 2016	Dec 2, 2016	1 AOP 41: Sustained AhR Activation leading to Rodent Liver Tumours
2911	854: Alterations, Cellular proliferation / hyperplasia	2136: prostatic intraepithelial neoplasia	May 11, 2023	May 11, 2023	1 AOP 495: Androgen receptor activation leading to prostate cancer
2844	2089: Altered Bone Cell Homeostasis	2090: Bone Remodeling	Jan 25, 2023	Aug 9, 2024	1 AOP 482: Deposition of energy leading to occurrence of bone loss
3527	2089: Altered Bone Cell Homeostasis	1761: Inhibition, Fin regeneration	Apr 18, 2025	Apr 18, 2025	1 AOP 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
3112	2204: Altered brain morphology	341: Impairment, Learning and memory	Jan 14, 2024	Jan 14, 2024	1 AOP 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory
3435	2292: Altered Cardiac Electrical Conduction	1106: Occurrence, cardiac arrhythmia	Nov 22, 2024	Nov 22, 2024	2 AOPs 560: Inhibition of Funny current (If) leading to Arrhythmias 562: HCN Channel Inhibition leading to Arrhythmias
3320	2245: Altered cell differentiation signaling	2089: Altered Bone Cell Homeostasis	Jul 24, 2024	Aug 23, 2024	2 AOPs 482: Deposition of energy leading to occurrence of bone loss 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
3110	2202: Altered expression of cell cycle genes	2203: Decreased proliferation of cortical NPCs	Jan 14, 2024	Jan 14, 2024	2 AOPs 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
1269	1214: Altered expression of hepatic CAR-dependent genes	716: Increase, cell proliferation (hepatocytes)	Nov 29, 2016	Dec 21, 2018	1 AOP 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
16	17: Altered expression of AHR/ARNT pathway-dependent genes	317: Altered, Cardiovascular development/function	Nov 29, 2016	Dec 3, 2016	None
17	17: Altered expression of AHR/ARNT pathway-dependent genes	80: Up Regulation, CYP1A1	Nov 29, 2016	Dec 3, 2016	None
2641	1917: Altered expression of NRF2 pathway-dependent genes	1815: ER stress	Apr 8, 2022	Apr 8, 2022	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
3271	1917: Altered expression of NRF2 pathway-dependent genes	1392: Oxidative Stress	Jul 4, 2024	Jul 4, 2024	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
3194	2221: LXR activity, altered	2223: Reduced number of oligodendrocytes	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3243	2005: neurotrasmission in development	757: Hippocampal anatomy, Altered	Jun 3, 2024	Jul 31, 2024	1 AOP 442: Binding to voltage gate sodium channels during development leads to cognitive impairment

Key Event Relationships (KERs)

All KERs