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All KERs

Showing 526 to 550 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

229	201: Binding of antagonist, NMDA receptors	195: Inhibition, NMDARs	Nov 29, 2016	Jun 13, 2018	2 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
1023	998: Binding of antagonist, PPAR alpha	1000: stabilization, PPAR alpha co-repressor	Nov 29, 2016	Jun 11, 2018	1 AOP 6: Antagonist binding to PPARα leading to body-weight loss
1944	1653: Binding of inhibitor, mitochondrial complex III	1542: Inhibition, Mitochondrial complex III	Jun 7, 2019	Jun 7, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
1945	1654: Binding of inhibitor, mitochondrial complex IV	1543: Mitochondrial Complex IV inhibition	Jun 7, 2019	Jun 7, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
1946	1655: Binding of inhibitor, mitochondrial complex V	1544: Mitochondrial Complex V inhibition	Jun 7, 2019	Jun 7, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
933	888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)	887: Inhibition, NADH-ubiquinone oxidoreductase (complex I)	Nov 29, 2016	Aug 25, 2017	3 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome 273: Mitochondrial complex inhibition leading to liver injury
1833	1580: Binding of MSAs to microtubules	1581: Disturbance in microtubule dynamic instability	Jan 29, 2019	Jan 29, 2019	1 AOP 279: Microtubule interacting drugs lead to peripheral neuropathy
3556	2307: Qb in D1 protein	1862: Decrease, Photosystem II efficiency	Aug 5, 2025	Aug 5, 2025	1 AOP 567: Binding of plastoquinone B leading to decrease, population growth rate via decrease, photosystem II efficiency
1677	1486: Binding of substrate, endocytic receptor	831: Disturbance, Lysosomal function	Oct 25, 2017	Oct 25, 2017	1 AOP 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
1330	1252: Binding, topoisomerase II	1253: MLL translocation	Jan 20, 2017	Apr 26, 2017	None
1634	1252: Binding, topoisomerase II	1461: Increase, DSB	Aug 2, 2017	Aug 1, 2022	1 AOP 202: Inhibitor binding to topoisomerase II leading to infant leukaemia
2056	1739: Binding to ACE2	1738: SARS-CoV-2 cell entry	Mar 2, 2020	Oct 21, 2024	7 AOPs 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) 406: SARS-CoV-2 infection leading to hyperinflammation 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
2286	1739: Binding to ACE2	188: Neuroinflammation	Feb 23, 2021	Feb 23, 2021	1 AOP 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis
2294	1739: Binding to ACE2	1741: Induced, Angiotensin (Ang) II accumulation	Mar 28, 2021	Mar 28, 2021	None
2297	1739: Binding to ACE2	1752: Increased AngII	Mar 28, 2021	Mar 28, 2021	None
2299	1739: Binding to ACE2	1740: ACE2 enzymatic inhibition	Mar 28, 2021	Mar 28, 2021	None
2311	1739: Binding to ACE2	1854: ACE2 dysregulation	Mar 31, 2021	Feb 7, 2023	2 AOPs 385: Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation 428: Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis
2312	1739: Binding to ACE2	1787: Downregulation of ACE2	Mar 31, 2021	Nov 12, 2021	2 AOPs 385: Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation 381: Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
2452	1739: Binding to ACE2	1913: Endothelial cell dysfunction	Aug 4, 2021	Aug 4, 2021	None
2522	1739: Binding to ACE2	1937: ADAM17 induction	Oct 28, 2021	Oct 28, 2021	None
2020	1710: Binding to estrogen receptor (ER)-α	1711: Induction of GATA3 expression	Dec 29, 2019	Aug 14, 2020	1 AOP 314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
2534	1956: Binding to hERG channel	1958: Direct hERG channel blockage	Dec 13, 2021	Dec 13, 2021	None
2605	1353: Binding to VGSC	1977: Altered kinetics of sodium channel	Mar 21, 2022	Jul 31, 2024	1 AOP 442: Binding to voltage gate sodium channels during development leads to cognitive impairment
1253	1201: Binding, Immunophilins	980: Inhibition, Calcineurin Activity	Nov 29, 2016	Oct 25, 2017	None
287	261: Binding, SH-/selen-proteins	158: N/A, Interferences with SH-/selen-proteins	Nov 29, 2016	Dec 3, 2016	None

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