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All KERs

Showing 776 to 800 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1873	40: Decrease, Mitochondrial ATP production	1607: Increase, Necrosis	Mar 19, 2019	Mar 19, 2019	None
2551	40: Decrease, Mitochondrial ATP production	1863: Decrease, Reproduction	Jan 21, 2022	Jan 21, 2022	1 AOP 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction
2823	40: Decrease, Mitochondrial ATP production	1532: Decrease, Cardiac contractility	Jan 5, 2023	Jan 5, 2023	1 AOP 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production
3455	40: Decrease, Mitochondrial ATP production	2300: Disruption, Glucolipid metabolism	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
3456	40: Decrease, Mitochondrial ATP production	2151: Disruption, neurotransmitter release	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
3576	40: Decrease, Mitochondrial ATP production	2343: Cuproptosis	Aug 13, 2025	Aug 13, 2025	1 AOP 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
2094	1770: Decrease, MMP	1477: Decrease, OXPHOS	Apr 30, 2020	Apr 30, 2020	2 AOPs 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 328: Excessive reactive oxygen species production leading to mortality (2)
2347	1770: Decrease, MMP	1864: Increase, Programmed cell death	Apr 11, 2021	Apr 11, 2021	None
3163	1770: Decrease, MMP	177: Mitochondrial dysfunction	Mar 14, 2024	Mar 14, 2024	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
3613	1770: Decrease, MMP	40: Decrease, Mitochondrial ATP production	Sep 2, 2025	Sep 2, 2025	1 AOP 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction
3657	2377: neural network formation	2231: Impaired locomotor function	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
3659	2377: neural network formation	341: Impairment, Learning and memory	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
2758	2063: Decrease, New cuticle secretion	990: Increase, Incomplete ecdysis	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
559	572: Decrease, Number of worker bees	563: Death/Failure, Colony	Nov 29, 2016	Dec 3, 2016	2 AOPs 81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
573	572: Decrease, Number of worker bees	568: impaired, Hive thermoregulation	Nov 29, 2016	Dec 3, 2016	2 AOPs 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
1470	1366: Decrease, Oogenesis	488: Decrease, Ovulation	Apr 15, 2017	Apr 15, 2017	None
1752	1366: Decrease, Oogenesis	328: Decrease, Fecundity	Jun 12, 2018	Jun 12, 2018	3 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3)
2586	1366: Decrease, Oogenesis	1863: Decrease, Reproduction	Mar 1, 2022	Mar 1, 2022	None
2588	1366: Decrease, Oogenesis	78: Reduction, Cumulative fecundity and spawning	Mar 1, 2022	Mar 1, 2022	4 AOPs 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
2114	1782: Decrease, Oogenesis (F3)	1781: Decrease, Fecundity (F3)	Apr 30, 2020	Apr 30, 2020	2 AOPs 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
544	488: Decrease, Ovulation	78: Reduction, Cumulative fecundity and spawning	Nov 29, 2016	Dec 3, 2016	None
687	488: Decrease, Ovulation	675: Reduced, Reproductive Success	Nov 29, 2016	Dec 3, 2016	1 AOP 63: Cyclooxygenase inhibition leading to reproductive dysfunction
1471	488: Decrease, Ovulation	330: Decrease, Fertility	Apr 15, 2017	Apr 15, 2017	None
1753	488: Decrease, Ovulation	328: Decrease, Fecundity	Jun 12, 2018	Jun 12, 2018	None
1669	1477: Decrease, OXPHOS	40: Decrease, Mitochondrial ATP production	Oct 10, 2017	Oct 10, 2017	3 AOPs 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism

Key Event Relationships (KERs)

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