Key Event Relationships (KERs)

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Showing 826 to 850 of 3002 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1547 1382: Decrease, surfactant 1405: Reduced, mucosal defense Jun 2, 2017 Jun 2, 2017
1888 1622: Decrease, Transgenerational DNA methylation 1621: Increase, Gene expression Apr 22, 2019 Apr 22, 2019 None
399 289: Decrease, Translocator protein (TSPO) 413: Reduction, Testosterone synthesis in Leydig cells Nov 29, 2016 Dec 3, 2016 None
437 289: Decrease, Translocator protein (TSPO) 447: Reduction, Cholesterol transport in mitochondria Nov 29, 2016 Dec 2, 2016
2098 1772: Decrease, TAG 1771: Decrease, ATP pool Apr 30, 2020 Apr 30, 2020
2744 2051: Decrease, Tyrosine 2052: Decrease, dopa decarboxylase Aug 28, 2022 Aug 28, 2022
3515 2318: Decreased 3βHSD activity 1611: Reduction, androstenedione Apr 8, 2025 Apr 8, 2025 None
3516 2318: Decreased 3βHSD activity 1693: Decreased, Progesterone levels Apr 8, 2025 Apr 8, 2025 None
3497 2309: FAM50B/PTCHD3 methylation 2310: FAM50B/PTCHD3 expression Mar 2, 2025 Mar 2, 2025
3502 2309: FAM50B/PTCHD3 methylation 2121: decreased, IQ Mar 2, 2025 Mar 2, 2025
1618 1452: decreased DNA methylation of tyrosine hydroxylase 1447: obesity Jul 24, 2017 Jul 24, 2017
1620 1452: decreased DNA methylation of tyrosine hydroxylase 1450: decreased dopamine Jul 24, 2017 Jul 24, 2017
1614 1450: decreased dopamine 1451: decreased reward Jul 24, 2017 Jul 24, 2017
2700 2026: decrease folate 1561: Neural tube defects Jul 19, 2022 Jul 19, 2022
1814 1571: Decreased IL-1 production 1572: Impaired IL-1 signaling Dec 25, 2018 Jun 25, 2019 None
1824 1571: Decreased IL-1 production 1573: Suppressed MyD88 Jan 6, 2019 Jan 6, 2019 None
1619 1453: decreased methylation of dopamine transporter promoter 1447: obesity Jul 24, 2017 Jul 24, 2017
1621 1453: decreased methylation of dopamine transporter promoter 1450: decreased dopamine Jul 24, 2017 Jul 24, 2017
1811 1562: Decreased Na/K ATPase activity 1563: Decreased proximal tubular vectorial transport Dec 20, 2018 Dec 20, 2018
2787 1562: Decreased Na/K ATPase activity 1527: Increase, Cell membrane depolarization Oct 19, 2022 Oct 19, 2022
3287 1562: Decreased Na/K ATPase activity 2236: Decreased, sodium uptake in gills Jul 8, 2024 Dec 3, 2024
3444 1562: Decreased Na/K ATPase activity 1321: Increased, intracellular sodium (Na+) Nov 26, 2024 Nov 26, 2024
3542 2325: Decreased number of LT CD8+ cells 1971: tumor growth Jun 10, 2025 Jun 10, 2025 None
2293 1837: decreased oocyte maturation 406: decreased, Fertility Mar 26, 2021 Mar 26, 2021
2278 1836: Decreased plasma Cortisol level 1837: decreased oocyte maturation Feb 9, 2021 Feb 9, 2021