Key Event Relationships (KERs)

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Showing 1251 to 1275 of 3002 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1714 1502: Histone deacetylase inhibition 1504: p21 (CDKN1A) expression, increase Jan 21, 2018 Jul 25, 2018 None
1715 1502: Histone deacetylase inhibition 1505: Cell cycle, disrupted Jan 21, 2018 Jul 28, 2021
1716 1502: Histone deacetylase inhibition 1262: Apoptosis Jan 21, 2018 Jul 1, 2021
1717 1502: Histone deacetylase inhibition 1506: Testicular atrophy Jan 21, 2018 Jul 28, 2021
1802 1502: Histone deacetylase inhibition 1557: Reduced neural crest cell migration Dec 20, 2018 Dec 20, 2018
1805 1502: Histone deacetylase inhibition 1558: Reduced collagen production Dec 20, 2018 Dec 20, 2018
2010 1502: Histone deacetylase inhibition 1515: Spermatocyte depletion Dec 11, 2019 Jul 1, 2021
2699 1502: Histone deacetylase inhibition 1561: Neural tube defects Jul 19, 2022 Jul 19, 2022
3328 2252: Formation of HLA-DQ2/8-gluten complexes 272: Activation/Proliferation, T-cells Aug 13, 2024 Aug 13, 2024 None
3338 2252: Formation of HLA-DQ2/8-gluten complexes 2260: Activation of gluten-reactive CD4+ T cells Sep 13, 2024 Sep 13, 2024 None
3383 2252: Formation of HLA-DQ2/8-gluten complexes 2275: Co-localization of gluten reactive adaptive T-cells with APC Nov 12, 2024 Apr 8, 2025
2326 1853: Hyperactivation of ACE/Ang-II/AT1R axis 1752: Increased AngII Apr 10, 2021 Apr 10, 2021
2521 1853: Hyperactivation of ACE/Ang-II/AT1R axis 1535: Heart failure Oct 28, 2021 Oct 28, 2021 None
2762 1868: Hyperinflammation 1748: Increase, the risk of acute respiratory failure Sep 1, 2022 Sep 1, 2022 None
3429 2289: RyR2 hyperphosphorylation 389: Increased, Intracellular Calcium overload Nov 22, 2024 Nov 22, 2024
158 142: Hyperplasia, Hyperplasia 334: Promotion, Hepatocelluar carcinoma Nov 29, 2016 Dec 3, 2016
462 415: Hyperplasia, Leydig cell 406: decreased, Fertility Nov 29, 2016 Dec 3, 2016
1115 1078: Hyperplasia, Mammary gland 1080: Increased, latency period Nov 29, 2016 Dec 3, 2016
1116 1078: Hyperplasia, Mammary gland 1079: Increased, Adenomas/carcinomas (mammary) Nov 29, 2016 Dec 3, 2016
1093 1052: Hyperplasia, ovarian epithelium 1053: Promotion, ovarian adenomas Nov 29, 2016 Dec 3, 2016
1094 1051: Hyperplasia, ovarian stromal cells 1054: Promotion, ovarian granular cell tumors Nov 29, 2016 Dec 3, 2016
755 763: hyperpolarisation, neuron 764: N/A, Ataxia, paralysis, or hyperactivity Nov 29, 2016 Dec 3, 2016
1566 763: hyperpolarisation, neuron 1428: Analgesia Jun 8, 2017 Jun 8, 2017
1572 763: hyperpolarisation, neuron 1432: Anti-depressant Activity Jun 23, 2017 Jun 23, 2017
1083 1043: Hypertrophy/hyperplasia, smooth muscle 1044: Promotion, mesovarian leiomyomas Nov 29, 2016 Dec 3, 2016