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All KERs

Showing 1351 to 1375 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3177	1633: Increase in inflammation	2119: Insulin resistance, increased	Apr 9, 2024	Apr 9, 2024	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
1904	1632: Increase in RONS	1194: Increase, DNA Damage	May 7, 2019	May 8, 2019	3 AOPs 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
1906	1632: Increase in RONS	1492: Tissue resident cell activation	May 7, 2019	May 9, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
2331	1632: Increase in RONS	1861: D1 protein deactivation	Apr 11, 2021	Apr 11, 2021	None
2337	1632: Increase in RONS	1770: Decrease, MMP	Apr 11, 2021	Apr 11, 2021	None
2798	1632: Increase in RONS	2073: methemocyanin formation (decrease overall oxygen binding capacity)	Nov 16, 2022	Nov 16, 2022	1 AOP 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
3268	1632: Increase in RONS	1392: Oxidative Stress	Jul 4, 2024	Jul 4, 2024	1 AOP 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
3565	1632: Increase in RONS	1767: Increase, Protein oxidation	Aug 13, 2025	Aug 13, 2025	None
3566	1632: Increase in RONS	1445: Increase, LPO	Aug 13, 2025	Aug 13, 2025	None
3567	1632: Increase in RONS	1634: Increase, Oxidative DNA damage	Aug 13, 2025	Aug 13, 2025	None
1795	1553: Increase mutations	1555: Increase cell proliferation	Dec 19, 2018	Dec 19, 2018	None
1800	1553: Increase mutations	1556: Increase, lung cancer	Dec 19, 2018	Dec 19, 2018	None
1900	1553: Increase mutations	1182: Increase, Cell Proliferation (Epithelial Cells)	May 7, 2019	May 7, 2019	None
3237	1553: Increase mutations	885: Increase, Cancer	May 28, 2024	May 28, 2024	1 AOP 534: Succinate dehydrogenase (SDH) inhibition leads to cancer through oxidative stress
2023	1713: Increase of autoantibody production	1714: Exacerbation of SLE	Dec 29, 2019	Aug 14, 2020	1 AOP 314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
3564	2339: Increase of intracellular copper	1632: Increase in RONS	Aug 13, 2025	Aug 13, 2025	None
3571	2339: Increase of intracellular copper	2340: Oligomerisation of DLAT	Aug 13, 2025	Aug 13, 2025	1 AOP 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
3574	2339: Increase of intracellular copper	2342: Loss of Fe-S clusters	Aug 13, 2025	Aug 13, 2025	1 AOP 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
2022	1712: Increase of Th2 cells producing IL-4	1713: Increase of autoantibody production	Dec 29, 2019	Aug 14, 2020	1 AOP 314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
2799	2073: methemocyanin formation (decrease overall oxygen binding capacity)	2074: Decrease overall oxygen binding capacity (methemocyanin formation)	Nov 16, 2022	Nov 16, 2022	1 AOP 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
2800	2073: methemocyanin formation (decrease overall oxygen binding capacity)	2075: Hemocyanin Bohr effect decrease	Nov 16, 2022	Nov 16, 2022	1 AOP 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
2067	1743: Increase plasma Ang II	1745: Increase,collagen synthesis	Mar 17, 2020	Mar 17, 2020	None
2138	1743: Increase plasma Ang II	68: Accumulation, Collagen	May 15, 2020	May 15, 2020	None
2435	1743: Increase plasma Ang II	1852: Increased Ang II type 1 receptor (AT1R)	Jul 13, 2021	Jul 13, 2021	1 AOP 383: Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis
398	416: Increase proliferation, Leydig cell	415: Hyperplasia, Leydig cell	Nov 29, 2016	Dec 3, 2016	1 AOP 51: PPARα activation leading to impaired fertility in adult male rodents

Key Event Relationships (KERs)

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