Key Event Relationships (KERs)

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Showing 1851 to 1875 of 3002 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2315 1858: Increased viral transcription and replication 1496: Increased proinflammatory mediators Apr 9, 2021 Apr 9, 2021 None
2316 1858: Increased viral transcription and replication 1848: TLR Activation/Dysregulation Apr 9, 2021 Apr 9, 2021 None
1445 1326: Increased, 5-HT3 1344: Increased, seizure Apr 14, 2017 Apr 14, 2017
707 708: Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium) 709: Increase, Cytotoxicity (renal tubular cell) Nov 29, 2016 Dec 3, 2016
146 134: Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells) 209: Peptide Oxidation Nov 29, 2016 Dec 3, 2016 None
147 134: Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells) 276: Up Regulation, TGFbeta1 expression Nov 29, 2016 Nov 29, 2016 None
1706 1499: Activation of Th2 cells 1500: Increased cellular proliferation and differentiation Jan 5, 2018 May 18, 2023
1073 1029: Increased, adipogenesis 1032: Increased, secretion of local growth factors Nov 29, 2016 Dec 3, 2016
568 574: Increased, Appetite and hunger 560: Abnormal, Foraging activity and behavior Nov 29, 2016 Dec 3, 2016
607 602: Increased, Ataxia, paralysis, or hyperactivity 351: Increased Mortality Nov 29, 2016 Dec 3, 2016
432 444: Increased, Atrioventricular block and bradycardia 351: Increased Mortality Nov 29, 2016 Nov 29, 2016 None
591 444: Increased, Atrioventricular block and bradycardia 445: Respiratory distress/arrest Nov 29, 2016 Dec 3, 2016
2871 2124: increased, Bax 55: Cell injury/death Apr 4, 2023 Apr 4, 2023
2874 2124: increased, Bax 1825: Increase, Cell death Apr 4, 2023 Apr 4, 2023 None
3467 2124: increased, Bax 1262: Apoptosis Jan 4, 2025 May 29, 2025
706 714: Increased, Binding of chemicals to 2u (serum) 708: Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium) Nov 29, 2016 Dec 3, 2016
1135 1098: Increased, blood potassium concentration 1100: Occurrence, cardiac arrthymia Nov 29, 2016 Dec 3, 2016 None
1140 1098: Increased, blood potassium concentration 1106: Occurrence, cardiac arrhythmia Nov 29, 2016 Dec 3, 2016
3403 1098: Increased, blood potassium concentration 1983: Disruption in action potential generation Nov 20, 2024 Nov 20, 2024
1132 1096: Increased, blood uric acid concentration 1102: Occurrence, tophi (urate) deposition Nov 29, 2016 Dec 3, 2016
3263 1096: Increased, blood uric acid concentration 1392: Oxidative Stress Jul 3, 2024 Jul 3, 2024
3291 2238: Increased, Blood viscosity 2239: Increased, Cardiac stress Jul 8, 2024 Dec 3, 2024
703 699: Increased, cardiac arrthymia 351: Increased Mortality Nov 29, 2016 Dec 3, 2016
3292 2239: Increased, Cardiac stress 1535: Heart failure Jul 8, 2024 Dec 3, 2024
885 863: Increased, Catabolism of Muscle Protein 864: Decreased, Body Weight Nov 29, 2016 Jun 11, 2018