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All KERs

Showing 1876 to 1900 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1130	1089: Increased, Cell Proliferation (mesothelium)	1090: Increased, mesotheliomas	Nov 29, 2016	Dec 3, 2016	1 AOP 171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
1099	1062: Increased, Cellular proliferation / hyperplasia of acinar cells	1063: Increased, Pancreatic acinar tumors	Nov 29, 2016	Dec 3, 2016	1 AOP 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
758	761: Increased, Chloride conductance	763: hyperpolarisation, neuron	Nov 29, 2016	Dec 3, 2016	1 AOP 113: Glutamate-gated chloride channel activation leading to acute mortality
1052	761: Increased, Chloride conductance	1015: Increased, Neuronal synaptic inhibition	Nov 29, 2016	Dec 3, 2016	2 AOPs 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
1047	1011: Increased, Chloride influx	1012: Increased, Inhibitory postsynaptic potential	Nov 29, 2016	Dec 3, 2016	None
1100	1059: Increased, cholestasis	1061: prolonged, elevation of serun CCK	Nov 29, 2016	Dec 3, 2016	1 AOP 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
3368	2270: Increased, cholesterol synthesis enzymes	2271: Increased, plasma LDL cholesterol	Oct 22, 2024	Feb 10, 2025	1 AOP 545: Activation, Pregnane-X receptor, NR1l2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis
700	696: Increased, Chromosome misseggregation	675: Reduced, Reproductive Success	Nov 29, 2016	Dec 3, 2016	1 AOP 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
1210	1162: Increased, cilia movement	1146: premature, Spawning	Nov 29, 2016	Dec 3, 2016	None
1329	1162: Increased, cilia movement	1255: induced spawning	Jan 17, 2017	Jan 17, 2017	None
1113	1076: Increased, circulating estrogen levels	1078: Hyperplasia, Mammary gland	Nov 29, 2016	Dec 3, 2016	1 AOP 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
1119	1076: Increased, circulating estrogen levels	1081: Increased, lactotroph hyperplasia and hypertrophy	Nov 29, 2016	Dec 3, 2016	1 AOP 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
2584	1076: Increased, circulating estrogen levels	1051: Hyperplasia, ovarian stromal cells	Feb 26, 2022	Mar 2, 2022	None
2585	1076: Increased, circulating estrogen levels	1052: Hyperplasia, ovarian epithelium	Feb 26, 2022	Mar 2, 2022	1 AOP 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
3437	1076: Increased, circulating estrogen levels	2294: Plasma E2, increased	Nov 22, 2024	Nov 22, 2024	1 AOP 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
3439	1076: Increased, circulating estrogen levels	2251: Increased E2 availability	Nov 22, 2024	Nov 22, 2024	1 AOP 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
2270	961: Increased, Clearance of thyroxine from serum	281: T4 in serum, Decreased	Jan 26, 2021	Jan 26, 2021	6 AOPs 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
350	384: Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci	378: Tumorigenesis, Hepatocellular carcinoma	Nov 29, 2016	Dec 3, 2016	None
695	693: Increased, cyclic adenosine monophosphate	675: Reduced, Reproductive Success	Nov 29, 2016	Dec 3, 2016	None
696	693: Increased, cyclic adenosine monophosphate	694: Reduced, Meiotic prophase I/metaphase I transition, oocyte	Nov 29, 2016	Dec 3, 2016	1 AOP 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
3446	693: Increased, cyclic adenosine monophosphate	2289: RyR2 hyperphosphorylation	Nov 26, 2024	Nov 26, 2024	1 AOP 558: Phosphodiesterase inhibition leading to heart failure
484	458: Increased, De Novo FA synthesis	454: Increased, Triglyceride formation	Nov 29, 2016	Dec 3, 2016	None
512	458: Increased, De Novo FA synthesis	327: Accumulation, Fatty acid	Nov 29, 2016	Dec 3, 2016	1 AOP 58: NR1I3 (CAR) suppression leading to hepatic steatosis
1607	458: Increased, De Novo FA synthesis	459: Increased, Liver Steatosis	Jul 18, 2017	Jul 18, 2017	1 AOP 61: NFE2L2/FXR activation leading to hepatic steatosis
1155	1109: Increased, Deformed Wing Virus levels	1107: Weakened, Colony	Nov 29, 2016	Dec 3, 2016	1 AOP 179: Varroa mite infestation increases virus levels leading to colony loss/failure

Key Event Relationships (KERs)

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