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All KERs

Showing 1976 to 2000 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2709	389: Increased, Intracellular Calcium overload	1477: Decrease, OXPHOS	Jul 25, 2022	Jul 25, 2022	None
2710	389: Increased, Intracellular Calcium overload	2017: Endoplasmic reticulum stress	Jul 25, 2022	Jul 25, 2022	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
3042	389: Increased, Intracellular Calcium overload	1816: Mitochondrial dysfunction EMPTY	Sep 14, 2023	Sep 14, 2023	None
3091	389: Increased, Intracellular Calcium overload	2078: Loss of drebrin	Oct 18, 2023	Apr 4, 2025	1 AOP 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
3248	389: Increased, Intracellular Calcium overload	1392: Oxidative Stress	Jun 19, 2024	Jun 19, 2024	1 AOP 535: Binding and activation of GPER leading to learning and memory impairments
3256	389: Increased, Intracellular Calcium overload	2151: Disruption, neurotransmitter release	Jun 19, 2024	Jun 19, 2024	1 AOP 535: Binding and activation of GPER leading to learning and memory impairments
3426	389: Increased, Intracellular Calcium overload	1532: Decrease, Cardiac contractility	Nov 21, 2024	Nov 21, 2024	2 AOPs 556: Decreased Na/K ATPase activity leading to heart failure 558: Phosphodiesterase inhibition leading to heart failure
1465	1322: Increased, intracellular chloride (Cl-)	1356: Inactive, membrane depolarization	Apr 14, 2017	Apr 14, 2017	1 AOP 215: Molecular events lead to epilepsy
1525	1398: Increased, intracellular serotonin	1399: Increased, packaged serotonin	Jun 1, 2017	Jun 1, 2017	3 AOPs 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation
1455	1321: Increased, intracellular sodium (Na+)	1352: Activated, voltage-gated sodium channel	Apr 14, 2017	Apr 14, 2017	2 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy
3424	1321: Increased, intracellular sodium (Na+)	2287: Impaired Sodium-Calcium Exchange	Nov 21, 2024	Nov 21, 2024	1 AOP 556: Decreased Na/K ATPase activity leading to heart failure
2576	1196: Increased, Invasion	1193: N/A, Breast Cancer	Feb 15, 2022	Feb 15, 2022	None
3138	1196: Increased, Invasion	1982: Metastasis, Breast Cancer	Mar 5, 2024	Mar 5, 2024	1 AOP 439: Activation of the AhR leading to metastatic breast cancer
2462	759: Increased, Kidney Failure	350: Increase, Mortality	Aug 5, 2021	Aug 5, 2021	None
2466	759: Increased, Kidney Failure	351: Increased Mortality	Aug 11, 2021	Aug 11, 2021	1 AOP 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
2627	1985: Increased, Kisspeptin signalling	1986: Decreased, Gonadotropins	Apr 5, 2022	Aug 15, 2022	1 AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
1120	1081: Increased, lactotroph hyperplasia and hypertrophy	1082: Increased, adenomas (pituitary)	Nov 29, 2016	Dec 3, 2016	1 AOP 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1117	1080: Increased, latency period	1079: Increased, Adenomas/carcinomas (mammary)	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
508	467: Increased, LDL uptake	327: Accumulation, Fatty acid	Nov 29, 2016	Dec 3, 2016	1 AOP 57: AhR activation leading to hepatic steatosis
3443	467: Increased, LDL uptake	1442: Foam cell formation	Nov 25, 2024	Nov 25, 2024	1 AOP 462: Activation of reactive oxygen species leading the atherosclerosis
1545	1411: Increased, leukocyte activation	1385: Activated, gastric ulcer formation	Jun 2, 2017	Jun 2, 2017	1 AOP 228: NSAID induced PTGS2 inactivation to gastric ulcer
1544	1410: Increased, leukocyte adherence	1411: Increased, leukocyte activation	Jun 2, 2017	Jun 2, 2017	1 AOP 228: NSAID induced PTGS2 inactivation to gastric ulcer
794	791: Increased, Leutinizing hormone (LH)	744: Increase, Hyperplasia (Leydig cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
1405	1306: Increased, lipogenesis	1305: Increase, cytosolic fatty acid	Apr 12, 2017	Apr 12, 2017	None
1695	459: Increased, Liver Steatosis	1115: Increase, ROS	Nov 14, 2017	Nov 14, 2017	1 AOP 213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)

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