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Showing 2251 to 2275 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

686	79: Inhibition, Cyclooxygenase activity	685: Reduced, Prostaglandins, ovary	Nov 29, 2016	Dec 3, 2016	1 AOP 63: Cyclooxygenase inhibition leading to reproductive dysfunction
689	79: Inhibition, Cyclooxygenase activity	687: Reduced, Prostaglandin E2 concentration, hypothalamus	Nov 29, 2016	Dec 3, 2016	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
3503	1840: Inhibition, cytochrome oxidase	1825: Increase, Cell death	Mar 5, 2025	Mar 18, 2025	3 AOPs 368: Cytochrome oxidase inhibition leading to increased nasal lesions 573: Inhibition, cytochrome oxidase leads to Increased, pulmonary edema 574: Inhibition, cytochrome oxidase leads to Loss of olfactory function
1878	1609: Inhibition of Cyp17A1 activity	1610: Reduction, DHEA	Apr 10, 2019	Apr 8, 2025	1 AOP 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
1879	1609: Inhibition of Cyp17A1 activity	1611: Reduction, androstenedione	Apr 10, 2019	Apr 8, 2025	1 AOP 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
1037	1009: Inhibition, Deiodinase 1	1003: Decreased, Triiodothyronine (T3)	Nov 29, 2016	Oct 10, 2022	2 AOPs 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation
1044	1009: Inhibition, Deiodinase 1	1004: Reduced, Posterior swim bladder inflation	Nov 29, 2016	Oct 10, 2022	1 AOP 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
1045	1009: Inhibition, Deiodinase 1	1007: Reduced, Anterior swim bladder inflation	Nov 29, 2016	Mar 8, 2019	None
1198	1009: Inhibition, Deiodinase 1	1116: Decreased, Triiodothyronine (T3) in tissues	Nov 29, 2016	Dec 3, 2016	1 AOP 189: Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis
1026	1002: Inhibition, Deiodinase 2	1003: Decreased, Triiodothyronine (T3)	Nov 29, 2016	Oct 7, 2022	2 AOPs 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation
1042	1002: Inhibition, Deiodinase 2	1004: Reduced, Posterior swim bladder inflation	Nov 29, 2016	Oct 7, 2022	1 AOP 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation
1043	1002: Inhibition, Deiodinase 2	1007: Reduced, Anterior swim bladder inflation	Nov 29, 2016	Mar 8, 2019	None
1199	1002: Inhibition, Deiodinase 2	1116: Decreased, Triiodothyronine (T3) in tissues	Nov 29, 2016	Dec 3, 2016	1 AOP 190: Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
3653	1002: Inhibition, Deiodinase 2	2093: Decreased brain T4/T3	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
1200	1153: Inhibition, Deiodinase 3	1154: Increased, Triiodothyronine (T3) in tissues	Nov 29, 2016	Dec 3, 2016	1 AOP 191: Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis
1203	1156: Inhibition, Dual oxidase	277: TH synthesis, Decreased	Nov 29, 2016	Dec 3, 2016	1 AOP 193: Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis
3121	2207: inhibition, EKR1/2 signaling pathway	2208: Aberrant, synaptic formation and plasticity	Jan 25, 2024	Jan 25, 2024	1 AOP 522: Estrogen antagonism leading to increased risk of autism-like behavior
597	593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel	585: Decreased, Sodium conductance 1	Nov 29, 2016	Dec 3, 2016	1 AOP 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
3419	593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel	1961: Prolongation of Action Potential	Nov 21, 2024	Nov 21, 2024	1 AOP 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
1692	1490: Inhibition of fatty acid beta oxidation	1305: Increase, cytosolic fatty acid	Nov 13, 2017	Nov 13, 2017	1 AOP 213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
1056	1016: Inhibition, Feeding	351: Increased Mortality	Nov 29, 2016	Dec 3, 2016	2 AOPs 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
3087	1016: Inhibition, Feeding	350: Increase, Mortality	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
2080	1761: Inhibition, Fin regeneration	1005: Reduced, Swimming performance	Apr 21, 2020	Jul 10, 2020	1 AOP 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
519	471: Inhibition, FoxA2	472: Down Regulation, CPT1A	Nov 29, 2016	Dec 3, 2016	1 AOP 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
523	471: Inhibition, FoxA2	474: Down Regulation, HMGCS2	Nov 29, 2016	Dec 3, 2016	1 AOP 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis

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