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Showing 2376 to 2400 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2807	2078: Loss of drebrin	1944: Dysfunctional synapses	Dec 11, 2022	Apr 4, 2025	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
3298	2078: Loss of drebrin	2242: Dendritic spine abnormality	Jul 14, 2024	Apr 4, 2025	1 AOP 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
3300	2078: Loss of drebrin	341: Impairment, Learning and memory	Jul 14, 2024	Mar 9, 2025	1 AOP 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
3575	2342: Loss of Fe-S clusters	1477: Decrease, OXPHOS	Aug 13, 2025	Aug 13, 2025	1 AOP 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
3578	2342: Loss of Fe-S clusters	889: Impaired, Proteostasis	Aug 13, 2025	Aug 13, 2025	1 AOP 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
3580	2342: Loss of Fe-S clusters	2341: Disruption of TCA cycle	Aug 13, 2025	Aug 13, 2025	1 AOP 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
3539	2326: LTCD8+ cytotoxicity	2325: Decreased number of LT CD8+ cells	May 22, 2025	May 22, 2025	None
3541	2326: LTCD8+ cytotoxicity	1971: tumor growth	Jun 10, 2025	Jun 10, 2025	1 AOP 578: AhR activation leading to cancer progression via immunosuppression
405	348: Malformation, Male reproductive tract	406: decreased, Fertility	Nov 29, 2016	Dec 2, 2016	1 AOP 18: PPARα activation in utero leading to impaired fertility in males
808	809: malformed, Male reproductive tract	330: Decrease, Fertility	Nov 29, 2016	Dec 3, 2016	1 AOP 124: HMG-CoA reductase inhibition leading to decreased fertility
402	409: Metabolism of AFB1, Production of Reactive Electrophiles	373: Formation, Pro-mutagenic DNA Adducts	Nov 29, 2016	Nov 29, 2016	1 AOP 46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
1780	1541: Mitochondrial Complex I inhibition	1545: Decrease in mitochondrial oxidative phosphorylation	Dec 19, 2018	Mar 7, 2019	None
3453	1541: Mitochondrial Complex I inhibition	2299: Altered, Redox Homeostasis	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
1782	1543: Mitochondrial Complex IV inhibition	1545: Decrease in mitochondrial oxidative phosphorylation	Dec 19, 2018	Mar 7, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
3555	1543: Mitochondrial Complex IV inhibition	177: Mitochondrial dysfunction	Aug 1, 2025	Aug 1, 2025	1 AOP 589: Inhibition of the mitochondrial complex IV of nigro-striatal neurons leads to parkinsonian motor deficits
1783	1544: Mitochondrial Complex V inhibition	1545: Decrease in mitochondrial oxidative phosphorylation	Dec 19, 2018	Mar 7, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
363	177: Mitochondrial dysfunction	55: Cell injury/death	Nov 29, 2016	Nov 29, 2016	3 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption
582	177: Mitochondrial dysfunction	386: Neuronal network function, Decreased	Nov 29, 2016	Dec 3, 2016	1 AOP 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
660	177: Mitochondrial dysfunction	664: Overwhelmed, Mitochondrial DNA repair mechanisms	Nov 29, 2016	Dec 3, 2016	1 AOP 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
664	177: Mitochondrial dysfunction	583: impaired, Thoracic shivering	Nov 29, 2016	Dec 3, 2016	None
904	177: Mitochondrial dysfunction	889: Impaired, Proteostasis	Nov 29, 2016	Oct 3, 2025	2 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 273: Mitochondrial complex inhibition leading to liver injury
908	177: Mitochondrial dysfunction	890: Degeneration of dopaminergic neurons of the nigrostriatal pathway	Nov 29, 2016	Oct 3, 2025	4 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits 588: Inhibition of the mitochondrial complex II of nigro-striatal neurons leads to parkinsonian motor deficits 589: Inhibition of the mitochondrial complex IV of nigro-striatal neurons leads to parkinsonian motor deficits
1152	177: Mitochondrial dysfunction	568: impaired, Hive thermoregulation	Nov 29, 2016	Dec 3, 2016	1 AOP 79: Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure
1154	177: Mitochondrial dysfunction	1107: Weakened, Colony	Nov 29, 2016	Dec 3, 2016	1 AOP 178: Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure
1311	177: Mitochondrial dysfunction	1243: Altered, Ca2+-calmodulin activated signal transduction	Nov 29, 2016	Dec 3, 2016	2 AOPs 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure

Key Event Relationships (KERs)

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