Key Event Relationships (KERs)

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Showing 226 to 250 of 3002 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
3526 122: Activation, Glucocorticoid Receptor 2245: Altered cell differentiation signaling Apr 18, 2025 Apr 18, 2025
752 760: Activation, Glutamate-gated chloride channel 761: Increased, Chloride conductance Nov 29, 2016 Dec 3, 2016
1057 1018: Activation, Glutamate-gated chloride channels 761: Increased, Chloride conductance Nov 29, 2016 Dec 3, 2016
3084 1018: Activation, Glutamate-gated chloride channels 388: Overactivation, NMDARs Oct 17, 2023 Oct 17, 2023
3085 1018: Activation, Glutamate-gated chloride channels 2195: Increase, CNS Neural cell death Oct 17, 2023 Oct 17, 2023
1204 1157: Activation, Hepatic nuclear receptor(s) 1158: Increased, Hepatic thyroid hormone uptake/transport Nov 29, 2016 Dec 3, 2016
1205 1157: Activation, Hepatic nuclear receptor(s) 295: Induction, Upregulation of glucuronyltransferase activity Nov 29, 2016 Dec 3, 2016
1365 1280: Activation, HIF-1 1262: Apoptosis Feb 15, 2017 Feb 15, 2017
2985 2162: Activation, HIF1α 2163: Activation Sema6A Aug 20, 2023 Aug 20, 2023
1411 1303: Activation, HSD17B4 451: Inhibition, Mitochondrial fatty acid beta-oxidation Apr 12, 2017 Apr 12, 2017 None
1415 1303: Activation, HSD17B4 1312: Increase, Fatty acid β-oxidation Apr 13, 2017 Apr 13, 2017 None
1699 151: Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways 398: Activation, Dendritic Cells Dec 7, 2017 Dec 3, 2020 None
1391 1297: Activation, insulin receptor 1298: Activation, mTORC2 Apr 12, 2017 Apr 12, 2017 None
1051 762: Activation, ionotropic GABA Receptor chloride channel 761: Increased, Chloride conductance Nov 29, 2016 Dec 3, 2016
1369 1282: Activation, JAK/STAT pathway 1283: Activation, TGF-beta pathway Feb 15, 2017 Feb 15, 2017
1380 1292: Activation, JNK 1293: Activation, FOXO Feb 15, 2017 Feb 15, 2017
2149 1292: Activation, JNK 1793: AP-1 activation Jul 9, 2020 Jul 9, 2020
2150 1292: Activation, JNK 1794: Pin-1 activation Jul 9, 2020 Jul 9, 2020
1261 1205: Activation, Juvenile hormone receptor 1206: Induction, Doublesex1 gene Nov 29, 2016 Dec 3, 2016
834 826: Activation, Keratinocytes 398: Activation, Dendritic Cells Nov 29, 2016 Dec 3, 2016
1401 1302: Activation, L-FABP 1305: Increase, cytosolic fatty acid Apr 12, 2017 Apr 12, 2017 None
1423 1302: Activation, L-FABP 228: demethylation, PPARg promoter Apr 13, 2017 Apr 13, 2017 None
1651 1468: TGFbeta1 activation 1469: TGFbeta pathway activation Aug 16, 2017 Aug 16, 2017
172 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 139: N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects Nov 29, 2016 Nov 29, 2016
874 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 853: Changes/Inhibition, Cellular Homeostasis and Apoptosis Nov 29, 2016 Nov 29, 2016