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Showing 2551 to 2575 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3038	388: Overactivation, NMDARs	1527: Increase, Cell membrane depolarization	Sep 14, 2023	Sep 14, 2023	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
3068	388: Overactivation, NMDARs	12: AchE Inhibition	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
3069	388: Overactivation, NMDARs	618: Decreased, Neuronal network function in adult brain	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
3071	388: Overactivation, NMDARs	188: Neuroinflammation	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
2404	1886: Overexpression of rasl11b	1821: Decrease, Cell proliferation	May 28, 2021	Dec 12, 2021	1 AOP 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
661	664: Overwhelmed, Mitochondrial DNA repair mechanisms	570: Accumulation, Damaged mitochondrial DNA	Nov 29, 2016	Dec 3, 2016	1 AOP 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
1852	1596: Oxidation of DNA	1599: Inflammatory events	Feb 4, 2019	Feb 4, 2019	None
1850	1594: Oxidation of membrane lipids	1599: Inflammatory events	Feb 4, 2019	Jul 9, 2019	1 AOP 282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
954	926: Oxidation, Glutathione	927: S-Glutathionylation, eNOS	Nov 29, 2016	Sep 28, 2017	None
2459	926: Oxidation, Glutathione	1115: Increase, ROS	Aug 5, 2021	Aug 5, 2021	1 AOP 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
864	844: Oxidation, Uroporphyrinogen	846: Accumulation, Highly carboxylated porphyrins	Nov 29, 2016	Nov 29, 2016	None
865	844: Oxidation, Uroporphyrinogen	845: Inhibition, UROD	Nov 29, 2016	May 30, 2018	1 AOP 131: Aryl hydrocarbon receptor activation leading to uroporphyria
1851	1595: Oxidation/denatuation of membrane proteins	1599: Inflammatory events	Feb 4, 2019	Jul 9, 2019	1 AOP 282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
1513	1392: Oxidative Stress	1393: Hepatocytotoxicity	May 30, 2017	Jun 19, 2021	1 AOP 220: Cyp2E1 Activation Leading to Liver Cancer
1516	1392: Oxidative Stress	1395: Liver Cancer	May 30, 2017	Jun 19, 2021	1 AOP 220: Cyp2E1 Activation Leading to Liver Cancer
1685	1392: Oxidative Stress	1488: Glutamate dyshomeostasis	Nov 9, 2017	Feb 6, 2020	1 AOP 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
1690	1392: Oxidative Stress	55: Cell injury/death	Nov 9, 2017	Feb 7, 2020	2 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
2008	1392: Oxidative Stress	1645: Wnt ligand stimulation	Dec 3, 2019	Dec 3, 2019	None
2289	1392: Oxidative Stress	1845: Coagulation	Mar 25, 2021	Mar 25, 2021	None
2449	1392: Oxidative Stress	1906: CFTR Function, Decreased	Jul 30, 2021	Sep 28, 2021	1 AOP 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
2450	1392: Oxidative Stress	1911: FOXJ1 Protein, Decreased	Aug 2, 2021	Sep 28, 2021	1 AOP 425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
2451	1392: Oxidative Stress	1908: CBF, Decreased	Aug 2, 2021	Mar 24, 2023	1 AOP 411: Oxidative stress Leading to Decreased Lung Function
2505	1392: Oxidative Stress	1943: p-Tau	Oct 26, 2021	Oct 26, 2021	1 AOP 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
2674	1392: Oxidative Stress	2010: Pulmonary inflammation	Jun 17, 2022	Jun 17, 2022	1 AOP 452: Adverse outcome pathway of PM-induced respiratory toxicity
2714	1392: Oxidative Stress	1547: Mitochondrial Injury	Jul 25, 2022	Jul 25, 2022	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits

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