Key Event Relationships (KERs)

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Showing 326 to 350 of 3002 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1403 1301: Activation, SREBP-1 258: Activation, SCD-1 Apr 12, 2017 Apr 12, 2017 None
294 264: Activation, SREBP-1c 89: Synthesis, De Novo Fatty Acid (FA) Nov 29, 2016 Dec 3, 2016
295 265: Activation, Stellate cells 68: Accumulation, Collagen Nov 29, 2016 Dec 5, 2018
2892 265: Activation, Stellate cells 1501: Increased extracellular matrix deposition Apr 13, 2023 Jan 30, 2025
3217 265: Activation, Stellate cells 459: Increased, Liver Steatosis May 14, 2024 May 14, 2024 None
1016 978: Activation, Suppression of NFAT activation and hindrance of nuclear localization 979: Interference, nuclear localization of NFAT Nov 29, 2016 Dec 3, 2016 None
1370 1283: Activation, TGF-beta pathway 1277: Reproductive failure Feb 15, 2017 Feb 15, 2017
2153 1283: Activation, TGF-beta pathway 1457: EMT Jul 9, 2020 Jul 9, 2020
1832 1576: Activation, Tissue resident cells (Kuppfer cells) 1579: Increase, proinflammatory mediators (TNFalpha) Jan 7, 2019 Jan 7, 2019
1652 1469: TGFbeta pathway activation 1456: Differentiation of fibroblasts Aug 16, 2017 Aug 16, 2017
1653 1469: TGFbeta pathway activation 1457: EMT Aug 16, 2017 Aug 16, 2017
301 272: Activation/Proliferation, T-cells 312: N/A, Allergic contact dermatitis on challenge Nov 29, 2016 Dec 3, 2016 None
835 272: Activation/Proliferation, T-cells 827: sensitisation, skin Nov 29, 2016 Dec 3, 2016
1701 272: Activation/Proliferation, T-cells 313: Increase, Allergic Respiratory Hypersensitivity Response Dec 7, 2017 Aug 1, 2022
3332 272: Activation/Proliferation, T-cells 2256: Activation of gluten- and TG2-reactive B cells Aug 13, 2024 Aug 13, 2024 None
3334 272: Activation/Proliferation, T-cells 1931: Disruption of the intestinal barrier Aug 13, 2024 Aug 13, 2024 None
3337 272: Activation/Proliferation, T-cells 2252: Formation of HLA-DQ2/8-gluten complexes Aug 13, 2024 Aug 13, 2024 None
2157 1793: AP-1 activation 1795: TGFbeta expression Jul 9, 2020 Jul 9, 2020
2523 1937: ADAM17 induction 1938: ACE2 increased shedding Oct 28, 2021 Oct 28, 2021 None
2696 2025: Affected folate transporter 2026: decrease folate Jul 19, 2022 Jul 19, 2022
31 25: Agonism, Androgen receptor 129: Reduction, Gonadotropins, circulating concentrations Nov 29, 2016 Mar 20, 2017
32 25: Agonism, Androgen receptor 274: Reduction, Testosterone synthesis by ovarian theca cells Nov 29, 2016 Mar 20, 2017
1384 25: Agonism, Androgen receptor 3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Mar 17, 2017 Mar 20, 2017
1385 25: Agonism, Androgen receptor 285: Reduction, Vitellogenin synthesis in liver Mar 17, 2017 Mar 20, 2017
2260 25: Agonism, Androgen receptor 1790: Increased, Differentiation to Testis Jan 12, 2021 Jan 3, 2023