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All KERs

Showing 401 to 425 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2773	2066: Altered Signaling	2067: Altered, Nitric Oxide Levels	Sep 28, 2022	Mar 21, 2023	None
2775	2066: Altered Signaling	2068: Increase, Endothelial Dysfunction	Sep 28, 2022	Mar 21, 2023	None
2840	2066: Altered Signaling	2098: Abnormal Neural Remodeling	Jan 25, 2023	Mar 21, 2023	None
2843	2066: Altered Signaling	2089: Altered Bone Cell Homeostasis	Jan 25, 2023	Mar 22, 2023	None
3400	2066: Altered Signaling	1924: Increased，Cardiac fibrosis	Nov 20, 2024	Nov 20, 2024	1 AOP 550: Increased LMNA gene mutation leading to heart failure
3317	2244: Altered Stress Response Signaling	2067: Altered, Nitric Oxide Levels	Jul 24, 2024	Aug 26, 2024	1 AOP 470: Deposition of energy leads to abnormal vascular remodeling
3318	2244: Altered Stress Response Signaling	2068: Increase, Endothelial Dysfunction	Jul 24, 2024	Aug 26, 2024	1 AOP 470: Deposition of energy leads to abnormal vascular remodeling
3321	2244: Altered Stress Response Signaling	2098: Abnormal Neural Remodeling	Jul 24, 2024	Jul 25, 2024	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment
702	698: Altered, Action Potential	699: Increased, cardiac arrthymia	Nov 29, 2016	Dec 3, 2016	1 AOP 104: Altered ion channel activity leading impaired heart function
3407	698: Altered, Action Potential	1962: Prolongation of QT interval	Nov 20, 2024	Nov 20, 2024	1 AOP 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
3415	698: Altered, Action Potential	1532: Decrease, Cardiac contractility	Nov 21, 2024	Nov 21, 2024	1 AOP 553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
3432	698: Altered, Action Potential	2280: Prolonged atrioventricular (AV)	Nov 22, 2024	Nov 22, 2024	1 AOP 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
1310	1243: Altered, Ca2+-calmodulin activated signal transduction	341: Impairment, Learning and memory	Nov 29, 2016	Dec 3, 2016	4 AOPs 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
977	317: Altered, Cardiovascular development/function	358: Increase, Pericardial edema	Nov 29, 2016	Jun 9, 2017	None
1352	317: Altered, Cardiovascular development/function	350: Increase, Mortality	Feb 9, 2017	Feb 9, 2017	None
1567	317: Altered, Cardiovascular development/function	947: Increase, Early Life Stage Mortality	Jun 9, 2017	Mar 23, 2018	3 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
3189	2115: Cholesterol metabolism	2223: Reduced number of oligodendrocytes	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3196	2115: Cholesterol metabolism	2221: LXR activity, altered	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
723	723: Altered, Chromosome number	728: Increase, Aneuploid offspring	Nov 29, 2016	Dec 13, 2019	1 AOP 106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
1298	1239: Altered, Gene Expression	1240: Altered, Protein Production	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
1807	1239: Altered, Gene Expression	1560: Cell differentiation, altered	Dec 20, 2018	Dec 20, 2018	1 AOP 275: Histone deacetylase inhibition leads to neural tube defects
2468	1930: Altered, inner ear development	1008: Reduced, Hearing	Aug 23, 2021	Aug 23, 2021	1 AOP 410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
738	752: Altered, Meiotic chromosome dynamics	723: Altered, Chromosome number	Nov 29, 2016	Dec 13, 2019	1 AOP 106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
2383	752: Altered, Meiotic chromosome dynamics	1775: Increase, Oocyte apoptosis	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2384	752: Altered, Meiotic chromosome dynamics	1798: Decreased spermatogenesis	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis

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