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All KERs

Showing 601 to 625 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2277	1835: Cortisol and 11β-(OH) testosterone decreased	1756: Decreased, 11KT	Feb 9, 2021	Feb 9, 2021	1 AOP 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
376	396: Covalent Binding, Protein	397: Response, Keratinocytes	Nov 29, 2016	Dec 3, 2016	None
377	396: Covalent Binding, Protein	398: Activation, Dendritic Cells	Nov 29, 2016	Nov 5, 2020	2 AOPs 40: Covalent Protein binding leading to Skin Sensitisation 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
833	396: Covalent Binding, Protein	826: Activation, Keratinocytes	Nov 29, 2016	Dec 3, 2016	1 AOP 40: Covalent Protein binding leading to Skin Sensitisation
2202	396: Covalent Binding, Protein	151: Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways	Nov 5, 2020	Feb 11, 2021	None
2649	396: Covalent Binding, Protein	1496: Increased proinflammatory mediators	Apr 28, 2022	Sep 8, 2022	1 AOP 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
2650	396: Covalent Binding, Protein	313: Increase, Allergic Respiratory Hypersensitivity Response	Apr 28, 2022	Aug 1, 2022	1 AOP 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
3309	1508: CYP2E1 Activation	1392: Oxidative Stress	Jul 23, 2024	Jul 23, 2024	1 AOP 260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
1493	1386: CYP7B activity, inhibition	1387: 7α-hydroxypregnenolone synthesis in the brain, decreased	May 2, 2017	May 17, 2017	2 AOPs 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
1494	1386: CYP7B activity, inhibition	1389: Locomotor activity, decreased	May 2, 2017	May 17, 2017	1 AOP 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
2440	1906: CFTR Function, Decreased	1907: ASL Height, Decreased	Jul 19, 2021	Sep 7, 2021	1 AOP 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
839	829: Damage, Lipid bilayer	833: Occurrence, Cytoplasmic vacuolization (hepatocyte)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
840	829: Damage, Lipid bilayer	835: Occurrence, Ballooning degeneration (hepatocyte)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
841	829: Damage, Lipid bilayer	836: Occurrence, Cytoplasmic vacuolization (Bile duct cell)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
842	829: Damage, Lipid bilayer	837: Occurrence, Cytoplasmic vacuolization (kupffer cell)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
277	250: Damaging, Red blood cells; hemolysis	161: Increase, Liver and splenic hemosiderosis	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
278	250: Damaging, Red blood cells; hemolysis	173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
279	250: Damaging, Red blood cells; hemolysis	246: Increase, RBC congestion in liver	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
3108	2200: decline, neural progenitor cells	1978: Microcephaly	Jan 10, 2024	Jan 10, 2024	1 AOP 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
1265	361: Decline, Population	1210: Alteration, Food-web structures	Nov 29, 2016	Dec 3, 2016	1 AOP 201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
3147	1258: Decompartmentalization	177: Mitochondrial dysfunction	Mar 13, 2024	Mar 13, 2024	1 AOP 205: AOP from chemical insult to cell death
1787	1545: Decrease in mitochondrial oxidative phosphorylation	1547: Mitochondrial Injury	Dec 19, 2018	Mar 7, 2019	None
1956	1545: Decrease in mitochondrial oxidative phosphorylation	177: Mitochondrial dysfunction	Jun 15, 2019	Jun 15, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
3558	1545: Decrease in mitochondrial oxidative phosphorylation	1472: Decrease, ATP production	Aug 5, 2025	Aug 5, 2025	1 AOP 567: Binding of plastoquinone B leading to decrease, population growth rate via decrease, photosystem II efficiency
1991	1696: Decrease of egg production and cummulative fecundity	679: Decline, Population trajectory	Oct 3, 2019	Oct 3, 2019	1 AOP 309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction

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