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All KERs

Showing 751 to 775 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2804	1521: Decrease, Growth	1141: Decreased, Reproductive Success	Nov 16, 2022	Nov 16, 2022	1 AOP 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
2111	1778: Decrease, Heritable DNA methylation (F3)	1779: Increase, Casp transcription (F3)	Apr 30, 2020	Apr 30, 2020	2 AOPs 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
649	633: Decrease, histaminergic neuron excitation	634: N/A, sedation	Nov 29, 2016	Dec 3, 2016	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
1643	633: Decrease, histaminergic neuron excitation	341: Impairment, Learning and memory	Aug 11, 2017	Aug 11, 2017	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
791	788: Decrease, Incorporation of active iodide into iodotyrosines	771: Decrease, Serum thyroid hormone (T4/T3)	Nov 29, 2016	Dec 3, 2016	None
886	867: Decrease, Intracellular pH	768: Increase, Cytotoxicity	Nov 29, 2016	Nov 29, 2016	1 AOP 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
3448	2298: Decrease, intratesticular testosterone	1690: Decrease, circulating testosterone levels	Dec 12, 2024	May 7, 2025	3 AOPs 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring
3449	2298: Decrease, intratesticular testosterone	1688: AGD, decreased	Dec 12, 2024	May 6, 2025	1 AOP 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
3487	2298: Decrease, intratesticular testosterone	1786: nipple retention, increased	Jan 30, 2025	Sep 17, 2025	1 AOP 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring
3488	2298: Decrease, intratesticular testosterone	2082: Hypospadias	Feb 15, 2025	Sep 18, 2025	1 AOP 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring
2753	2059: Decrease, knickkopf gene	2060: Decrease, Chitin laminar organization	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
2754	2059: Decrease, knickkopf gene	2061: Decrease, Prevent chitin degradation by chitinases	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
1671	1478: Decrease, Leaf cell mitosis	1479: Decrease, Leaf development	Oct 10, 2017	Oct 10, 2017	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1672	1479: Decrease, Leaf development	1480: Increase, Growth hormone	Oct 10, 2017	Oct 10, 2017	None
2283	1479: Decrease, Leaf development	1521: Decrease, Growth	Feb 16, 2021	Feb 16, 2021	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
2335	1479: Decrease, Leaf development	1863: Decrease, Reproduction	Apr 11, 2021	Apr 11, 2021	1 AOP 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
1666	1474: Decrease, Light harvest capacity	1475: Decrease, Photosynthesis	Oct 10, 2017	Oct 10, 2017	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
3061	2198: Decrease, mbp	352: N/A, Neurodegeneration	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
3643	2375: Decrease, Mis-timed EcR-responsive NR cascade	988: Decrease, Circulating ETH	Sep 29, 2025	Sep 29, 2025	1 AOP 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
3644	2375: Decrease, Mis-timed EcR-responsive NR cascade	1522: Inhibition, CHS-1	Sep 29, 2025	Sep 29, 2025	1 AOP 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
1601	40: Decrease, Mitochondrial ATP production	1366: Decrease, Oogenesis	Jun 29, 2017	Jun 29, 2017	None
1670	40: Decrease, Mitochondrial ATP production	1478: Decrease, Leaf cell mitosis	Oct 10, 2017	Oct 10, 2017	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1682	40: Decrease, Mitochondrial ATP production	709: Increase, Cytotoxicity (renal tubular cell)	Oct 25, 2017	Oct 25, 2017	1 AOP 258: Renal protein alkylation leading to kidney toxicity
1739	40: Decrease, Mitochondrial ATP production	1521: Decrease, Growth	May 24, 2018	May 24, 2018	None
1750	40: Decrease, Mitochondrial ATP production	1365: Increase, Apoptosis	Jun 12, 2018	Jun 12, 2018	None

Key Event Relationships (KERs)

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