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Showing 926 to 950 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3469	531: Decreased, LH Surge	1695: Impaired ovulation	Jan 10, 2025	Jan 10, 2025	1 AOP 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation
1109	1072: Decreased, LH Surge from anterior pituitary	1074: interruption, Ovulation	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1110	1072: Decreased, LH Surge from anterior pituitary	1075: prolonged, estrus cycle	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
651	635: Decreased, locomotion	588: Increased, predation	Nov 29, 2016	Dec 3, 2016	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
389	168: Decreased, Lymphocytes	323: Increased, Disease susceptibility	Nov 29, 2016	Dec 3, 2016	None
390	168: Decreased, Lymphocytes	403: Suppression, Immune system	Nov 29, 2016	Dec 3, 2016	1 AOP 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
2631	1988: Decreased, Maturation Inducing Steroids Surge by Granulosa cells	1989: Impaired, Oocyte maturation and ovulation	Apr 5, 2022	Apr 5, 2022	1 AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
805	805: Decreased, mevalonate	807: Decreased, cholesterol	Nov 29, 2016	Dec 3, 2016	1 AOP 124: HMG-CoA reductase inhibition leading to decreased fertility
882	860: Decreased, Mitochondrial Fatty Acid Beta Oxidation	861: Decreased, Ketogenesis (production of ketone bodies)	Nov 29, 2016	Nov 29, 2016	None
2040	860: Decreased, Mitochondrial Fatty Acid Beta Oxidation	459: Increased, Liver Steatosis	Feb 22, 2020	Feb 22, 2020	None
2264	860: Decreased, Mitochondrial Fatty Acid Beta Oxidation	291: Accumulation, Triglyceride	Jan 15, 2021	Jan 15, 2021	1 AOP 318: Glucocorticoid Receptor activation leading to hepatic steatosis
1535	1404: Decreased, mucosal blood flow	1405: Reduced, mucosal defense	Jun 2, 2017	Jun 2, 2017	1 AOP 227: NSAID induced PTGS1 inactivation to gastric ulcer
1538	1406: Decreased, mucous	1405: Reduced, mucosal defense	Jun 2, 2017	Jun 2, 2017	1 AOP 227: NSAID induced PTGS1 inactivation to gastric ulcer
3663	2105: Decreased, mbp expression in oligodendrocytes	2266: Demyelination, increased	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
634	618: Decreased, Neuronal network function in adult brain	341: Impairment, Learning and memory	Nov 29, 2016	Nov 29, 2016	1 AOP 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
2656	618: Decreased, Neuronal network function in adult brain	1583: Sensory axonal peripheral neuropathy	May 16, 2022	May 16, 2022	1 AOP 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
3072	618: Decreased, Neuronal network function in adult brain	2150: Neurological disorder	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
3073	618: Decreased, Neuronal network function in adult brain	188: Neuroinflammation	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
3074	618: Decreased, Neuronal network function in adult brain	890: Degeneration of dopaminergic neurons of the nigrostriatal pathway	Oct 17, 2023	Oct 17, 2023	None
3076	618: Decreased, Neuronal network function in adult brain	637: impaired, Learning and memory	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
1448	1330: Decreased, neuroplasticity	1345: Increased, agitation	Apr 14, 2017	Apr 14, 2017	3 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 222: Mental stress to agitation 225: Serotonin transporter activation to agitation
1449	1330: Decreased, neuroplasticity	1346: Increased, depression	Apr 14, 2017	Apr 14, 2017	3 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 224: Serotonin transporter activation to depression
212	193: Decreased, Nitric Oxide	166: Decreased, Long-term potentiation (LTP)	Nov 29, 2016	Dec 3, 2016	1 AOP 26: Calcium-mediated neuronal ROS production and energy imbalance
1084	1045: Decreased, Ovarian E2	1047: Increased, secretion of GnRH from hypothalamus	Nov 29, 2016	Dec 3, 2016	None
1085	1045: Decreased, Ovarian E2	1056: Decrease, E2 blood concentrations at hypothalamus	Nov 29, 2016	Dec 3, 2016	1 AOP 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse

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