AOP-Wiki

API

All KERs

Showing 1026 to 1050 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3355	2266: Demyelination, increased	2267: Delayed neuropathy, increased	Oct 1, 2024	Oct 1, 2024	2 AOPs 543: Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation
3664	2266: Demyelination, increased	2378: Impaired axonal insulation	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
1181	1143: Depletion, energy reserves	1140: Delayed, Sexual maturity	Nov 29, 2016	Dec 3, 2016	None
1185	1143: Depletion, energy reserves	623: Increase, predation	Nov 29, 2016	Dec 3, 2016	1 AOP 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
2878	130: Depletion, GSH	1115: Increase, ROS	Apr 5, 2023	Sep 14, 2023	1 AOP 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
3133	1482: Depletion, mtDNA	177: Mitochondrial dysfunction	Feb 28, 2024	Feb 28, 2024	1 AOP 256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
1977	1686: Energy Deposition	1635: Increase, DNA strand breaks	Aug 26, 2019	Jul 29, 2024	6 AOPs 272: Deposition of energy leading to lung cancer 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 478: Deposition of energy leading to occurrence of cataracts 470: Deposition of energy leads to abnormal vascular remodeling 483: Deposition of Energy Leading to Learning and Memory Impairment
1981	1686: Energy Deposition	185: Increase, Mutations	Aug 29, 2019	Dec 17, 2024	2 AOPs 272: Deposition of energy leading to lung cancer 478: Deposition of energy leading to occurrence of cataracts
1982	1686: Energy Deposition	1636: Increase, Chromosomal aberrations	Aug 29, 2019	Dec 17, 2024	2 AOPs 272: Deposition of energy leading to lung cancer 478: Deposition of energy leading to occurrence of cataracts
1983	1686: Energy Deposition	1556: Increase, lung cancer	Aug 29, 2019	Jul 5, 2023	1 AOP 272: Deposition of energy leading to lung cancer
2548	1686: Energy Deposition	1115: Increase, ROS	Jan 21, 2022	Jan 21, 2022	4 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
2552	1686: Energy Deposition	1194: Increase, DNA Damage	Jan 21, 2022	Jan 21, 2022	4 AOPs 388: Deposition of ionising energy leading to population decline via programmed cell death 435: Deposition of ionising energy leads to population decline via pollen abnormal 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2604	1686: Energy Deposition	1978: Microcephaly	Mar 17, 2022	Mar 17, 2022	1 AOP 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
2616	1686: Energy Deposition	1632: Increase in RONS	Mar 28, 2022	Mar 28, 2022	2 AOPs 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
2769	1686: Energy Deposition	1392: Oxidative Stress	Sep 28, 2022	Aug 26, 2024	4 AOPs 470: Deposition of energy leads to abnormal vascular remodeling 483: Deposition of Energy Leading to Learning and Memory Impairment 482: Deposition of energy leading to occurrence of bone loss 478: Deposition of energy leading to occurrence of cataracts
2770	1686: Energy Deposition	2003: Vascular remodeling	Sep 28, 2022	Sep 28, 2022	None
2779	1686: Energy Deposition	2067: Altered, Nitric Oxide Levels	Sep 28, 2022	Aug 26, 2024	1 AOP 470: Deposition of energy leads to abnormal vascular remodeling
2780	1686: Energy Deposition	2068: Increase, Endothelial Dysfunction	Sep 28, 2022	Aug 26, 2024	1 AOP 470: Deposition of energy leads to abnormal vascular remodeling
2785	1686: Energy Deposition	2069: Occurrence, Abnormal Vascular Remodeling	Oct 17, 2022	Aug 26, 2024	1 AOP 470: Deposition of energy leads to abnormal vascular remodeling
2809	1686: Energy Deposition	2081: Modified Proteins	Dec 16, 2022	Mar 8, 2024	1 AOP 478: Deposition of energy leading to occurrence of cataracts
2813	1686: Energy Deposition	1634: Increase, Oxidative DNA damage	Dec 18, 2022	Mar 8, 2024	1 AOP 478: Deposition of energy leading to occurrence of cataracts
2814	1686: Energy Deposition	870: Increase, Cell Proliferation	Dec 18, 2022	Mar 8, 2024	1 AOP 478: Deposition of energy leading to occurrence of cataracts
2815	1686: Energy Deposition	2083: Cataracts	Dec 18, 2022	Mar 11, 2024	1 AOP 478: Deposition of energy leading to occurrence of cataracts
2832	1686: Energy Deposition	1492: Tissue resident cell activation	Jan 25, 2023	Jul 26, 2024	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment
2837	1686: Energy Deposition	2098: Abnormal Neural Remodeling	Jan 25, 2023	Jul 26, 2024	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment

Key Event Relationships (KERs)

All KERs