AOP-Wiki

API

All KERs

Showing 1101 to 1125 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

993	898: Disruption, Lysosome	177: Mitochondrial dysfunction	Nov 29, 2016	Nov 12, 2018	2 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption
1679	898: Disruption, Lysosome	709: Increase, Cytotoxicity (renal tubular cell)	Oct 25, 2017	Oct 25, 2017	1 AOP 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
715	720: Disruption, Microtubule dynamics	721: Disorganization, Meiotic Spindle	Nov 29, 2016	Dec 13, 2019	1 AOP 106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
188	178: Disruption, Mitochondrial electron transport chain	40: Decrease, Mitochondrial ATP production	Nov 29, 2016	Dec 3, 2016	2 AOPs 26: Calcium-mediated neuronal ROS production and energy imbalance 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
3493	178: Disruption, Mitochondrial electron transport chain	1115: Increase, ROS	Feb 25, 2025	Feb 25, 2025	1 AOP 26: Calcium-mediated neuronal ROS production and energy imbalance
2955	2151: Disruption, neurotransmitter release	341: Impairment, Learning and memory	Jun 27, 2023	Apr 11, 2024	2 AOPs 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 535: Binding and activation of GPER leading to learning and memory impairments
3080	2151: Disruption, neurotransmitter release	637: impaired, Learning and memory	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
3458	2151: Disruption, neurotransmitter release	2301: Abnormal, Behavior	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
2562	1682: Disruption, Progenitor cells of second heart field	1557: Reduced neural crest cell migration	Feb 8, 2022	Feb 10, 2022	1 AOP 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
1762	1537: Disruption, Sarcomere assembly	1532: Decrease, Cardiac contractility	Jun 21, 2018	Jun 21, 2018	1 AOP 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1842	1590: Distribution of chemicals	1591: Absorption of photon energy	Feb 4, 2019	Feb 4, 2019	None
1834	1581: Disturbance in microtubule dynamic instability	1582: Impaired axonial transport	Jan 29, 2019	Jan 29, 2019	1 AOP 279: Microtubule interacting drugs lead to peripheral neuropathy
843	831: Disturbance, Lysosomal function	833: Occurrence, Cytoplasmic vacuolization (hepatocyte)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
844	831: Disturbance, Lysosomal function	835: Occurrence, Ballooning degeneration (hepatocyte)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
845	831: Disturbance, Lysosomal function	836: Occurrence, Cytoplasmic vacuolization (Bile duct cell)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
846	831: Disturbance, Lysosomal function	837: Occurrence, Cytoplasmic vacuolization (kupffer cell)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
1678	831: Disturbance, Lysosomal function	898: Disruption, Lysosome	Oct 25, 2017	Oct 25, 2017	1 AOP 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
1497	1388: Dopamine release in the brain, decreased	1389: Locomotor activity, decreased	May 2, 2017	May 2, 2017	1 AOP 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
1502	1388: Dopamine release in the brain, decreased	1390: Sexual behavior, decreased	May 9, 2017	May 9, 2017	1 AOP 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
520	472: Down Regulation, CPT1A	179: Decrease, Fatty acid β-oxidation	Nov 29, 2016	Dec 3, 2016	1 AOP 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
1373	1286: Down Regulation, GSS and GSTs gene	1287: Glutathione synthesis	Feb 15, 2017	Feb 15, 2017	1 AOP 209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1376	1286: Down Regulation, GSS and GSTs gene	1290: Glutathione homeostasis	Feb 15, 2017	Feb 15, 2017	1 AOP 209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
524	474: Down Regulation, HMGCS2	477: Decreased, Ketogenesis	Nov 29, 2016	Dec 3, 2016	1 AOP 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
446	427: Down Regulation, K-Cl co-transporter 2 (KCC2)	428: Delay, Developmental GABA shift	Nov 29, 2016	Dec 3, 2016	None
2136	1787: Downregulation of ACE2	1743: Increase plasma Ang II	May 15, 2020	May 15, 2020	None

Key Event Relationships (KERs)

All KERs