Key Event Relationships (KERs)

API

Fulltext search has been disabled for Key Event Relationships (KERs) at this time. If you need this feature, send an email to aopwiki@googlegroups.com

Queries Key Event Relationship (KER) titles
Filter by Upstream Key Event title
Filter by Downstream Key Event title
Filter by AOP title
Clear All Filters

Showing 1176 to 1200 of 3002 KERs

Clear Table Filters
ID Upstream Event Downstream Event Creation Date Last Updated AOPs
3296 2241: Ferroptosis related pathways activation 1928: increased，Vascular endothelial dysfunction Jul 9, 2024 Jul 9, 2024
2352 1866: Hypofibrinolysis 1867: Bradykinin, activated Apr 20, 2021 Apr 20, 2021
2356 1866: Hypofibrinolysis 1496: Increased proinflammatory mediators Apr 20, 2021 Feb 7, 2023
2678 2012: Fibroblast proliferation and differentiation 2013: Airway remodeling Jun 17, 2022 Jun 17, 2022
1841 1587: Fibroproliferative airway lesions 1588: Bronchiolitis obliterans Jan 30, 2019 Jan 30, 2019
1594 1442: Foam cell formation 1443: Atherosclerosis Jun 29, 2017 Jun 29, 2017 None
1853 1597: DNA photo-adducts 1599: Inflammatory events Feb 4, 2019 Feb 4, 2019 None
1591 1440: HDL-SAA formation 1441: Systemic cholesterol increased Jun 29, 2017 Jun 29, 2017 None
1593 1440: HDL-SAA formation 1442: Foam cell formation Jun 29, 2017 Jun 29, 2017 None
1854 1598: Protein photo-adducts 1599: Inflammatory events Feb 4, 2019 Feb 4, 2019 None
860 839: Formation, Mallory body 840: Formation, Liver fibrosis Nov 29, 2016 Dec 3, 2016
344 373: Formation, Pro-mutagenic DNA Adducts 377: Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H Nov 29, 2016 Dec 3, 2016 None
345 373: Formation, Pro-mutagenic DNA Adducts 378: Tumorigenesis, Hepatocellular carcinoma Nov 29, 2016 Nov 29, 2016
352 373: Formation, Pro-mutagenic DNA Adducts 384: Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci Nov 29, 2016 Nov 29, 2016 None
548 373: Formation, Pro-mutagenic DNA Adducts 493: Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts Nov 29, 2016 Dec 3, 2016
551 373: Formation, Pro-mutagenic DNA Adducts 491: Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) Nov 29, 2016 Nov 29, 2016
1062 976: Formation, The binding of FK506 with FKBP12 980: Inhibition, Calcineurin Activity Nov 29, 2016 Dec 3, 2016 None
2437 1903: foxi1 expression, increased 1904: six1b expression, increased Jul 14, 2021 Oct 28, 2021
2447 1911: FOXJ1 Protein, Decreased 1912: Motile Cilia Number/Length, Decreased Jul 23, 2021 Aug 2, 2021
1925 1646: Frizzled activation 1647: GSK3beta inactivation May 29, 2019 May 29, 2019 None
1962 1668: Frustrated phagocytosis 87: Release, Cytokine Jul 3, 2019 Aug 13, 2019
2415 1668: Frustrated phagocytosis 1496: Increased proinflammatory mediators Jul 6, 2021 Jul 6, 2021
2416 1668: Frustrated phagocytosis 1115: Increase, ROS Jul 6, 2021 Jul 6, 2021
1733 1513: General Apoptosis 1514: Neurodegeneration Apr 4, 2018 Apr 5, 2018
2977 1513: General Apoptosis 885: Increase, Cancer Jul 31, 2023 Oct 19, 2023