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Showing 1301 to 1325 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1990	1695: Impaired ovulation	1696: Decrease of egg production and cummulative fecundity	Oct 3, 2019	Oct 3, 2019	1 AOP 309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
3470	1695: Impaired ovulation	2303: Plasma estradiol/progesterone ratio, increase	Jan 10, 2025	Jan 14, 2025	1 AOP 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation
1976	1678: Impaired oxygenation of the blood	1679: Acute inhalation toxicity	Jul 3, 2019	Jul 3, 2019	None
3029	2179: Impaired Platelet Aggregation	2161: Increase, Vascular disrupting effects	Aug 21, 2023	Aug 21, 2023	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3425	2287: Impaired Sodium-Calcium Exchange	389: Increased, Intracellular Calcium overload	Nov 21, 2024	Nov 21, 2024	1 AOP 556: Decreased Na/K ATPase activity leading to heart failure
1821	1569: Impaired T cell activation	983: Suppression, Suppression of T-cell dependent antibody response (TDAR)	Dec 25, 2018	Dec 25, 2018	None
1822	1569: Impaired T cell activation	986: Impairment of TDAR	Dec 25, 2018	Jun 1, 2019	None
1922	1569: Impaired T cell activation	1644: Impaired Ab production	May 23, 2019	Jun 25, 2019	None
3618	2080: Impaired, blood testis barrier	520: Decreased sperm quantity or quality in the adult, Decreased fertility	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Nanoplastic effect
572	577: impaired, Development	572: Decrease, Number of worker bees	Nov 29, 2016	Dec 3, 2016	1 AOP 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure
574	568: impaired, Hive thermoregulation	563: Death/Failure, Colony	Nov 29, 2016	Dec 3, 2016	2 AOPs 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
1153	568: impaired, Hive thermoregulation	1107: Weakened, Colony	Nov 29, 2016	Dec 3, 2016	1 AOP 79: Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure
701	697: impaired, ion channels	698: Altered, Action Potential	Nov 29, 2016	Dec 3, 2016	1 AOP 104: Altered ion channel activity leading impaired heart function
563	566: impaired, Larval development	563: Death/Failure, Colony	Nov 29, 2016	Dec 3, 2016	4 AOPs 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
3460	566: impaired, Larval development	2302: Increase, Malformations	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
3079	637: impaired, Learning and memory	896: Parkinsonian motor deficits	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
2632	1989: Impaired, Oocyte maturation and ovulation	1990: Increased, Oocyte Atresia	Apr 5, 2022	Apr 5, 2022	1 AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
905	889: Impaired, Proteostasis	890: Degeneration of dopaminergic neurons of the nigrostriatal pathway	Nov 29, 2016	Oct 3, 2025	2 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons
1943	889: Impaired, Proteostasis	55: Cell injury/death	Jun 7, 2019	Jun 7, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
3579	889: Impaired, Proteostasis	2343: Cuproptosis	Aug 13, 2025	Aug 13, 2025	1 AOP 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
2164	1758: Impaired, Spermatogenesis	330: Decrease, Fertility	Jul 13, 2020	Jul 13, 2020	None
2274	1758: Impaired, Spermatogenesis	406: decreased, Fertility	Jan 29, 2021	Aug 15, 2022	1 AOP 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
2692	1758: Impaired, Spermatogenesis	2032: Viable offspring, decreased	Jul 18, 2022	Jul 18, 2022	None
2937	1758: Impaired, Spermatogenesis	2147: Decreased, Viable Offspring	Jun 2, 2023	Sep 29, 2023	2 AOPs 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone 521: Essential element imbalance leads to reproductive failure via oxidative stress
3621	1758: Impaired, Spermatogenesis	520: Decreased sperm quantity or quality in the adult, Decreased fertility	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Nanoplastic effect

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