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Showing 1451 to 1475 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1980	870: Increase, Cell Proliferation	1556: Increase, lung cancer	Aug 29, 2019	Jan 10, 2023	1 AOP 272: Deposition of energy leading to lung cancer
2419	870: Increase, Cell Proliferation	1090: Increased, mesotheliomas	Jul 6, 2021	Jul 6, 2021	1 AOP 409: Frustrated phagocytosis leads to malignant mesothelioma
2819	870: Increase, Cell Proliferation	2083: Cataracts	Dec 18, 2022	Mar 8, 2024	1 AOP 478: Deposition of energy leading to occurrence of cataracts
1247	1182: Increase, Cell Proliferation (Epithelial Cells)	1192: Increased, Ductal Hyperplasia	Nov 29, 2016	Dec 3, 2016	3 AOPs 200: Estrogen receptor activation leading to breast cancer 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1907	1182: Increase, Cell Proliferation (Epithelial Cells)	185: Increase, Mutations	May 8, 2019	May 8, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
773	716: Increase, cell proliferation (hepatocytes)	774: Increase, Preneoplastic foci (hepatocytes)	Nov 29, 2016	Feb 14, 2017	2 AOPs 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat)
1239	716: Increase, cell proliferation (hepatocytes)	1171: Increase, Clonal Expansion of Altered Hepatic Foci	Nov 29, 2016	Dec 3, 2016	1 AOP 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
2254	716: Increase, cell proliferation (hepatocytes)	719: Increase, hepatocellular adenomas and carcinomas	Dec 31, 2020	Dec 31, 2020	1 AOP 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
1979	1636: Increase, Chromosomal aberrations	870: Increase, Cell Proliferation	Aug 29, 2019	Mar 8, 2024	2 AOPs 272: Deposition of energy leading to lung cancer 478: Deposition of energy leading to occurrence of cataracts
1985	1636: Increase, Chromosomal aberrations	1556: Increase, lung cancer	Aug 29, 2019	Jan 10, 2023	1 AOP 272: Deposition of energy leading to lung cancer
637	621: Increase, cilia movement	622: Increased, locomotion	Nov 29, 2016	Dec 3, 2016	None
639	621: Increase, cilia movement	624: Increased, foot detachment	Nov 29, 2016	Dec 3, 2016	None
1178	621: Increase, cilia movement	1144: premature, spawning 1	Nov 29, 2016	Dec 3, 2016	None
1187	621: Increase, cilia movement	1146: premature, Spawning	Nov 29, 2016	Dec 3, 2016	None
1217	621: Increase, cilia movement	1166: Increased, water pumping	Nov 29, 2016	Dec 3, 2016	None
1218	621: Increase, cilia movement	1143: Depletion, energy reserves	Nov 29, 2016	Dec 3, 2016	None
1321	621: Increase, cilia movement	1255: induced spawning	Jan 13, 2017	Jan 13, 2017	1 AOP 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
1335	621: Increase, cilia movement	1257: Induced parturition	Jan 30, 2017	Jan 30, 2017	2 AOPs 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
1232	1171: Increase, Clonal Expansion of Altered Hepatic Foci	719: Increase, hepatocellular adenomas and carcinomas	Nov 29, 2016	Dec 3, 2016	1 AOP 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
3056	2195: Increase, CNS Neural cell death	2196: Decrease, elavl3	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
3057	2195: Increase, CNS Neural cell death	2197: Decrease, sox10	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
3058	2195: Increase, CNS Neural cell death	2198: Decrease, mbp	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
3501	2195: Increase, CNS Neural cell death	2121: decreased, IQ	Mar 2, 2025	Mar 2, 2025	1 AOP 569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway
1450	1334: Increase, cortisone	122: Activation, Glucocorticoid Receptor	Apr 14, 2017	Apr 14, 2017	1 AOP 214: Network of SSRIs (selective serotonin reuptake inhibitors)
1351	1269: Increase, COX-2 expression	317: Altered, Cardiovascular development/function	Feb 9, 2017	Mar 28, 2018	1 AOP 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2

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