AOP-Wiki

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All KERs

Showing 1501 to 1525 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1654	1456: Differentiation of fibroblasts	68: Accumulation, Collagen	Aug 16, 2017	Aug 16, 2017	1 AOP 241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
1301	1194: Increase, DNA Damage	1239: Altered, Gene Expression	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
1468	1194: Increase, DNA Damage	1365: Increase, Apoptosis	Apr 15, 2017	Apr 15, 2017	1 AOP 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
1897	1194: Increase, DNA Damage	185: Increase, Mutations	May 7, 2019	May 8, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
1898	1194: Increase, DNA Damage	1492: Tissue resident cell activation	May 7, 2019	May 10, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
1899	1194: Increase, DNA Damage	1553: Increase mutations	May 7, 2019	May 7, 2019	None
2338	1194: Increase, DNA Damage	1864: Increase, Programmed cell death	Apr 11, 2021	Apr 11, 2021	1 AOP 388: Deposition of ionising energy leading to population decline via programmed cell death
2381	1194: Increase, DNA Damage	752: Altered, Meiotic chromosome dynamics	May 12, 2021	May 12, 2021	2 AOPs 396: Deposition of ionizing energy leads to population decline via impaired meiosis 435: Deposition of ionising energy leads to population decline via pollen abnormal
2382	1194: Increase, DNA Damage	1775: Increase, Oocyte apoptosis	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2595	1194: Increase, DNA Damage	1974: Activation of TP53	Mar 9, 2022	Mar 9, 2022	1 AOP 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
2622	1194: Increase, DNA Damage	1798: Decreased spermatogenesis	Mar 28, 2022	Mar 28, 2022	1 AOP 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2790	1194: Increase, DNA Damage	1505: Cell cycle, disrupted	Oct 25, 2022	Oct 25, 2022	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
3582	1194: Increase, DNA Damage	2344: Upregulation, gadd45ba	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBEPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
1635	1461: Increase, DSB	1253: MLL translocation	Aug 2, 2017	Aug 1, 2022	1 AOP 202: Inhibitor binding to topoisomerase II leading to infant leukaemia
3096	1461: Increase, DSB	1365: Increase, Apoptosis	Nov 16, 2023	Nov 16, 2023	1 AOP 330: Excessive reactive oxygen species production leading to mortality (4)
3099	1461: Increase, DSB	1774: Increase, Casp transcription	Nov 16, 2023	Nov 16, 2023	1 AOP 338: DNA methyltransferase inhibition leading to population decline (3)
1884	1620: Increase, DNA hypomethylation	1621: Increase, Gene expression	Apr 22, 2019	Apr 22, 2019	None
1887	1620: Increase, DNA hypomethylation	1622: Decrease, Transgenerational DNA methylation	Apr 22, 2019	Apr 22, 2019	None
1993	1697: Increase, DNMT expression	1698: Increase, hypermethylation of the promotor region of GnRHR	Oct 30, 2019	Oct 30, 2019	1 AOP 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
1883	1619: Increase, DNMT inhibition	1620: Increase, DNA hypomethylation	Apr 22, 2019	Apr 22, 2019	None
2101	1619: Increase, DNMT inhibition	1773: Decrease, Global DNA methylation	Apr 30, 2020	Apr 30, 2020	4 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
3098	1619: Increase, DNMT inhibition	1461: Increase, DSB	Nov 16, 2023	Nov 16, 2023	1 AOP 338: DNA methyltransferase inhibition leading to population decline (3)
3305	1619: Increase, DNMT inhibition	1457: EMT	Jul 18, 2024	Jul 18, 2024	1 AOP 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT
1911	1635: Increase, DNA strand breaks	155: Inadequate DNA repair	May 19, 2019	Mar 8, 2024	3 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 478: Deposition of energy leading to occurrence of cataracts
1931	1635: Increase, DNA strand breaks	185: Increase, Mutations	Jun 2, 2019	Jan 9, 2023	2 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer

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