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All KERs

Showing 1601 to 1625 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1477	1378: Increase, leukocyte adherence	1379: Activate, leukocyte	Apr 17, 2017	Apr 17, 2017	1 AOP 217: Gastric ulcer formation
3591	2347: Increase, Lipid degradation	459: Increased, Liver Steatosis	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBEPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
3545	2332: Increase, Lipid droplet	2333: Increase, Fat mass	Jul 25, 2025	Jul 25, 2025	1 AOP 580: Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index
3551	2332: Increase, Lipid droplet	2337: Increase, PLIN2	Jul 25, 2025	Jul 25, 2025	1 AOP 580: Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index
1599	1445: Increase, LPO	1446: Decrease, Coupling of OXPHOS	Jun 29, 2017	Jun 29, 2017	3 AOPs 331: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 332: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell growth 333: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation
2097	1445: Increase, LPO	1772: Decrease, TAG	Apr 30, 2020	Apr 30, 2020	1 AOP 329: Excessive reactive oxygen species production leading to mortality (3)
2210	1445: Increase, LPO	1365: Increase, Apoptosis	Nov 25, 2020	Nov 25, 2020	None
2222	1445: Increase, LPO	1825: Increase, Cell death	Dec 4, 2020	Dec 4, 2020	None
2464	1445: Increase, LPO	1607: Increase, Necrosis	Aug 11, 2021	Aug 11, 2021	1 AOP 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
2879	1445: Increase, LPO	406: decreased, Fertility	Apr 5, 2023	Sep 14, 2023	1 AOP 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
3117	1445: Increase, LPO	2206: Increased, histomorphological alteration of testis	Jan 24, 2024	Apr 11, 2024	1 AOP 521: Essential element imbalance leads to reproductive failure via oxidative stress
3360	1445: Increase, LPO	55: Cell injury/death	Oct 8, 2024	Oct 8, 2024	None
3364	1445: Increase, LPO	1505: Cell cycle, disrupted	Oct 8, 2024	Oct 8, 2024	None
3569	1445: Increase, LPO	1994: Ferroptosis	Aug 13, 2025	Aug 13, 2025	None
169	161: Increase, Liver and splenic hemosiderosis	173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
461	414: Increase, Luteinizing hormone (LH)	416: Increase proliferation, Leydig cell	Nov 29, 2016	Dec 3, 2016	1 AOP 51: PPARα activation leading to impaired fertility in adult male rodents
3461	2302: Increase, Malformations	351: Increased Mortality	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
3641	2373: Increase, Mis-timed EcR-responsive NR cascade	988: Decrease, Circulating ETH	Sep 29, 2025	Sep 29, 2025	1 AOP 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
2119	1785: Increase, Mitochondrial ATP synthase antagonism	1477: Decrease, OXPHOS	May 8, 2020	May 8, 2020	None
2229	1785: Increase, Mitochondrial ATP synthase antagonism	1771: Decrease, ATP pool	Dec 4, 2020	Dec 4, 2020	2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
2183	1811: Increase, Complex III dysfunction	1812: Increase, Cyt c release	Nov 2, 2020	Nov 2, 2020	None
2797	2072: Increase, Mitochondrial swelling	55: Cell injury/death	Nov 1, 2022	Nov 1, 2022	1 AOP 268: Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling
198	350: Increase, Mortality	328: Decrease, Fecundity	Nov 29, 2016	Dec 3, 2016	None
199	350: Increase, Mortality	361: Decline, Population	Nov 29, 2016	Dec 3, 2016	None
1004	350: Increase, Mortality	765: Decreased, population 1	Nov 29, 2016	Dec 3, 2016	None

Key Event Relationships (KERs)

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