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Showing 1701 to 1725 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1965	1115: Increase, ROS	1669: Increased, DNA damage and mutation	Jul 3, 2019	Jul 3, 2019	2 AOPs 303: Frustrated phagocytosis-induced lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma
2009	1115: Increase, ROS	1392: Oxidative Stress	Dec 3, 2019	Aug 2, 2024	24 AOPs 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway 521: Essential element imbalance leads to reproductive failure via oxidative stress 186: unknown MIE leading to renal failure and mortality 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 462: Activation of reactive oxygen species leading the atherosclerosis 396: Deposition of ionizing energy leads to population decline via impaired meiosis 26: Calcium-mediated neuronal ROS production and energy imbalance 534: Succinate dehydrogenase (SDH) inhibition leads to cancer through oxidative stress 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases. 324: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and cell death 325: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell growth 326: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell proliferation 331: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 332: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell growth 333: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation 595: Nanoplastic effect 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption
2033	1115: Increase, ROS	1648: β-catenin activation	Jan 19, 2020	Jan 19, 2020	None
2320	1115: Increase, ROS	1172: Increased activation, Nuclear factor kappa B (NF-kB)	Apr 10, 2021	Apr 10, 2021	2 AOPs 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 319: Binding to ACE2 leading to lung fibrosis
2324	1115: Increase, ROS	1501: Increased extracellular matrix deposition	Apr 10, 2021	Apr 10, 2021	1 AOP 383: Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis
2328	1115: Increase, ROS	1855: Increased Sodium-sensitive hypertension	Apr 10, 2021	Apr 10, 2021	1 AOP 384: Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
2460	1115: Increase, ROS	1445: Increase, LPO	Aug 5, 2021	Apr 11, 2024	4 AOPs 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress 521: Essential element imbalance leads to reproductive failure via oxidative stress 329: Excessive reactive oxygen species production leading to mortality (3)
2549	1115: Increase, ROS	1861: D1 protein deactivation	Jan 21, 2022	Jan 21, 2022	1 AOP 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
2550	1115: Increase, ROS	1770: Decrease, MMP	Jan 21, 2022	Jan 21, 2022	2 AOPs 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 328: Excessive reactive oxygen species production leading to mortality (2)
2594	1115: Increase, ROS	68: Accumulation, Collagen	Mar 3, 2022	Mar 3, 2022	None
2660	1115: Increase, ROS	2006: Secondary genotoxicity	May 25, 2022	May 25, 2022	1 AOP 451: Interaction with lung resident cell membrane components leads to lung cancer
2966	1115: Increase, ROS	1262: Apoptosis	Jul 18, 2023	Apr 11, 2024	1 AOP 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
3092	1115: Increase, ROS	233: Decreased, PPAR-gamma activation	Oct 18, 2023	Oct 19, 2023	1 AOP 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
3490	1115: Increase, ROS	1634: Increase, Oxidative DNA damage	Feb 25, 2025	Feb 25, 2025	3 AOPs 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 330: Excessive reactive oxygen species production leading to mortality (4)
3491	1115: Increase, ROS	1767: Increase, Protein oxidation	Feb 25, 2025	Feb 25, 2025	1 AOP 327: Excessive reactive oxygen species production leading to mortality (1)
3492	1115: Increase, ROS	1446: Decrease, Coupling of OXPHOS	Feb 25, 2025	Feb 25, 2025	None
3494	1115: Increase, ROS	193: Decreased, Nitric Oxide	Feb 25, 2025	Feb 25, 2025	1 AOP 26: Calcium-mediated neuronal ROS production and energy imbalance
3496	1115: Increase, ROS	177: Mitochondrial dysfunction	Feb 25, 2025	Feb 25, 2025	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
3505	1115: Increase, ROS	1754: Increase, porcupine-induced Wnt secretion and Wnt signaling activation	Mar 6, 2025	Jul 22, 2025	1 AOP 298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
3509	1115: Increase, ROS	209: Peptide Oxidation	Apr 3, 2025	Apr 3, 2025	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
3513	1115: Increase, ROS	1594: Oxidation of membrane lipids	Apr 4, 2025	Apr 4, 2025	1 AOP 282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
3514	1115: Increase, ROS	1595: Oxidation/denatuation of membrane proteins	Apr 4, 2025	Apr 4, 2025	1 AOP 282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
3537	1115: Increase, ROS	2195: Increase, CNS Neural cell death	May 22, 2025	May 22, 2025	1 AOP 569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway
3611	1115: Increase, ROS	1862: Decrease, Photosystem II efficiency	Sep 2, 2025	Sep 2, 2025	1 AOP 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
3614	1115: Increase, ROS	112: Antagonism, Estrogen receptor	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Nanoplastic effect

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