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All KERs

Showing 1926 to 1950 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

504	465: Increased, FA Influx	291: Accumulation, Triglyceride	Nov 29, 2016	Dec 3, 2016	None
505	465: Increased, FA Influx	327: Accumulation, Fatty acid	Nov 29, 2016	Dec 3, 2016	3 AOPs 57: AhR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
1658	465: Increased, FA Influx	454: Increased, Triglyceride formation	Aug 31, 2017	Aug 31, 2017	1 AOP 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
2263	460: Increased, Fatty acid uptake	459: Increased, Liver Steatosis	Jan 15, 2021	Jan 15, 2021	None
1707	1500: Increased cellular proliferation and differentiation	1501: Increased extracellular matrix deposition	Jan 5, 2018	Dec 7, 2021	None
2652	1500: Increased cellular proliferation and differentiation	68: Accumulation, Collagen	May 4, 2022	May 18, 2023	1 AOP 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
1176	624: Increased, foot detachment	1143: Depletion, energy reserves	Nov 29, 2016	Dec 3, 2016	1 AOP 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
1183	624: Increased, foot detachment	623: Increase, predation	Nov 29, 2016	Dec 3, 2016	None
2247	959: Increased, Free serum thyroxine (T4)	1158: Increased, Hepatic thyroid hormone uptake/transport	Dec 9, 2020	Dec 9, 2020	2 AOPs 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
2268	959: Increased, Free serum thyroxine (T4)	960: Increased, Uptake of thyroxine into tissue	Jan 26, 2021	Jan 26, 2021	None
2272	959: Increased, Free serum thyroxine (T4)	961: Increased, Clearance of thyroxine from serum	Jan 26, 2021	Jan 26, 2021	1 AOP 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
1522	1396: Increased, glucocorticoid receptor activity	1335: Reduced, BDNF	May 31, 2017	May 31, 2017	2 AOPs 221: Mental stress to depression 222: Mental stress to agitation
1453	1350: Increased, glutamate	1351: Activated, NMDA receptor	Apr 14, 2017	Apr 14, 2017	2 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy
1859	1350: Increased, glutamate	388: Overactivation, NMDARs	Feb 13, 2019	Sep 3, 2023	1 AOP 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration
2861	1350: Increased, glutamate	1998: Microglia activation	Apr 3, 2023	Apr 3, 2023	1 AOP 490: Co-activation of IP3R and RyR leads to reduced IQ through non-cholinergic mechanisms
2868	1350: Increased, glutamate	2123: decreased, Bcl-2	Apr 4, 2023	Apr 4, 2023	1 AOP 490: Co-activation of IP3R and RyR leads to reduced IQ through non-cholinergic mechanisms
2869	1350: Increased, glutamate	2124: increased, Bax	Apr 4, 2023	Apr 4, 2023	1 AOP 490: Co-activation of IP3R and RyR leads to reduced IQ through non-cholinergic mechanisms
1206	1158: Increased, Hepatic thyroid hormone uptake/transport	401: Increase, Biliary excretion TH glucuronide	Nov 29, 2016	Dec 3, 2016	None
2237	1158: Increased, Hepatic thyroid hormone uptake/transport	281: T4 in serum, Decreased	Dec 9, 2020	Dec 9, 2020	3 AOPs 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
2479	1158: Increased, Hepatic thyroid hormone uptake/transport	961: Increased, Clearance of thyroxine from serum	Sep 10, 2021	Sep 10, 2021	3 AOPs 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
803	802: Increased, HIF-1 alpha transcription	799: Increased, HIF-1 heterodimer	Nov 29, 2016	Dec 3, 2016	1 AOP 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
800	799: Increased, HIF-1 heterodimer	800: Decreased, Aromatase (Cyp19a1) mRNA	Nov 29, 2016	Dec 3, 2016	2 AOPs 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
1459	1362: Increased, hippocampal hyperdepolarization	1348: Increase, seizure	Apr 14, 2017	Apr 14, 2017	1 AOP 215: Molecular events lead to epilepsy
1549	1362: Increased, hippocampal hyperdepolarization	1344: Increased, seizure	Jun 2, 2017	Jun 2, 2017	2 AOPs 230: presynaptic neuron 1 activation to epilepsy 231: presynaptic neuron 2 repression to epilepsy
3118	2206: Increased, histomorphological alteration of testis	1758: Impaired, Spermatogenesis	Jan 24, 2024	Apr 11, 2024	1 AOP 521: Essential element imbalance leads to reproductive failure via oxidative stress

Key Event Relationships (KERs)

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