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Showing 2001 to 2025 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3218	459: Increased, Liver Steatosis	55: Cell injury/death	May 14, 2024	Jan 30, 2025	1 AOP 494: AhR activation leading to liver fibrosis
3592	459: Increased, Liver Steatosis	2019: Non-alcoholic fatty liver disease	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBEPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
638	622: Increased, locomotion	623: Increase, predation	Nov 29, 2016	Dec 3, 2016	1 AOP 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
1177	622: Increased, locomotion	1143: Depletion, energy reserves	Nov 29, 2016	Dec 3, 2016	1 AOP 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
745	754: Increased, Luteinizing hormone (LH)	744: Increase, Hyperplasia (Leydig cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
2147	1791: Increased, Male Biased Sex Ratio	360: Decrease, Population growth rate	Jun 15, 2020	Jan 3, 2023	2 AOPs 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation 376: Androgen receptor agonism leading to male-biased sex ratio
1264	1208: Increased, Male offspring	361: Decline, Population	Nov 29, 2016	Dec 3, 2016	1 AOP 201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
1214	1160: Increased, mantel display	1163: Increased, Reproductive Success	Nov 29, 2016	Dec 3, 2016	None
1267	1190: Increased, Migration (Endothelial Cells)	1213: Increased, Angiogenesis	Nov 29, 2016	Dec 20, 2022	1 AOP 200: Estrogen receptor activation leading to breast cancer
2575	1190: Increased, Migration (Endothelial Cells)	1376: Increase, angiogenesis	Feb 15, 2022	Mar 5, 2024	1 AOP 439: Activation of the AhR leading to metastatic breast cancer
3598	2352: Increased, MMP	2353: Disrupted, energy metabolism	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBEPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
1306	1241: Increased, Motility	1196: Increased, Invasion	Nov 29, 2016	Feb 29, 2024	2 AOPs 200: Estrogen receptor activation leading to breast cancer 439: Activation of the AhR leading to metastatic breast cancer
641	625: Increased, muscular waves in foot	622: Increased, locomotion	Nov 29, 2016	Dec 3, 2016	1 AOP 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
642	625: Increased, muscular waves in foot	624: Increased, foot detachment	Nov 29, 2016	Dec 3, 2016	1 AOP 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
1228	625: Increased, muscular waves in foot	1143: Depletion, energy reserves	Nov 29, 2016	Dec 3, 2016	None
1053	1015: Increased, Neuronal synaptic inhibition	1012: Increased, Inhibitory postsynaptic potential	Nov 29, 2016	Dec 3, 2016	2 AOPs 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
3090	1015: Increased, Neuronal synaptic inhibition	1016: Inhibition, Feeding	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
1295	1191: Increased, Non-genomic signaling	1188: Increased, ER binding to T.F. to DNA (non-classical pathway)	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
1302	1191: Increased, Non-genomic signaling	1239: Altered, Gene Expression	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
1697	1491: increased, oncotic necrosis	1489: steatohepatitis	Nov 14, 2017	Nov 14, 2017	1 AOP 213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
2633	1990: Increased, Oocyte Atresia	1991: Impaired, Reproduction	Apr 5, 2022	Apr 5, 2022	1 AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
1213	1161: Increased, oocyte maturation	1163: Increased, Reproductive Success	Nov 29, 2016	Dec 3, 2016	None
1328	1161: Increased, oocyte maturation	1255: induced spawning	Jan 17, 2017	Jan 17, 2017	1 AOP 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
3597	2351: Increased, OXPHOS	2352: Increased, MMP	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBEPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
1526	1399: Increased, packaged serotonin	1400: Increased, synaptic release	Jun 1, 2017	Jun 1, 2017	3 AOPs 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation

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