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Showing 2026 to 2050 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1960	1665: Plasma HCY level	1666: dysfunction of microcirculation	Jul 3, 2019	Jul 3, 2019	1 AOP 301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
776	775: Increased, Plasma tyrosine	776: Increase, Cytotoxicity (corneal cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
1095	1057: Increased, PPAR-alpha activation	1058: Decreased, bile flow	Nov 29, 2016	Dec 3, 2016	1 AOP 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1096	1057: Increased, PPAR-alpha activation	1059: Increased, cholestasis	Nov 29, 2016	Dec 3, 2016	1 AOP 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1097	1057: Increased, PPAR-alpha activation	1060: Alteration, lipid metabolism	Nov 29, 2016	Dec 3, 2016	1 AOP 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
595	588: Increased, predation	592: Reduced, survival	Nov 29, 2016	Dec 3, 2016	2 AOPs 91: Sodium channel inhibition leading to reduced survival 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
654	588: Increased, predation	636: Decreased, survival	Nov 29, 2016	Dec 3, 2016	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
1114	1077: Increased, prolactin exposure	1078: Hyperplasia, Mammary gland	Nov 29, 2016	Dec 3, 2016	1 AOP 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
1122	1084: Increased, prolactin secretion	1085: Increased, hyperplasia (mammary gland)	Nov 29, 2016	Dec 3, 2016	1 AOP 170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1266	1189: Increased, Proliferation (Endothelial cells)	1213: Increased, Angiogenesis	Nov 29, 2016	Dec 20, 2022	1 AOP 200: Estrogen receptor activation leading to breast cancer
1076	1033: Increased, proliferation of mesenchymal cells	1035: Increased, Firbrosarcoma	Nov 29, 2016	Dec 3, 2016	1 AOP 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1077	1033: Increased, proliferation of mesenchymal cells	1036: Increased, liposarcoma	Nov 29, 2016	Dec 3, 2016	1 AOP 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1078	1033: Increased, proliferation of mesenchymal cells	1037: Increased, hemagiosarcoma	Nov 29, 2016	Dec 3, 2016	1 AOP 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
343	377: Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H	378: Tumorigenesis, Hepatocellular carcinoma	Nov 29, 2016	Nov 29, 2016	None
3389	2276: Increased, PCSK9 protein expression	2271: Increased, plasma LDL cholesterol	Nov 13, 2024	Feb 10, 2025	1 AOP 548: Activation, Pregnane-X receptor, NR1l2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression
1463	1357: Increased, RDX dose	1359: Activate, GABA-A receptor	Apr 14, 2017	Apr 14, 2017	1 AOP 215: Molecular events lead to epilepsy
1555	1357: Increased, RDX dose	1415: Reduced, GABA-A receptor activation	Jun 2, 2017	Jun 2, 2017	1 AOP 231: presynaptic neuron 2 repression to epilepsy
1704	1497: Recruitment of inflammatory cells	1498: Loss of alveolar capillary membrane integrity	Jan 5, 2018	May 18, 2023	1 AOP 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
1964	1497: Recruitment of inflammatory cells	1115: Increase, ROS	Jul 3, 2019	Jul 3, 2019	2 AOPs 303: Frustrated phagocytosis-induced lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma
2354	1497: Recruitment of inflammatory cells	1868: Hyperinflammation	Apr 20, 2021	Feb 8, 2023	2 AOPs 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
2491	1497: Recruitment of inflammatory cells	1931: Disruption of the intestinal barrier	Oct 19, 2021	Oct 19, 2021	None
2492	1497: Recruitment of inflammatory cells	1932: GI disorders	Oct 19, 2021	Oct 19, 2021	None
2543	1497: Recruitment of inflammatory cells	1954: Gut dysbiosis	Dec 15, 2021	Dec 15, 2021	None
2658	1497: Recruitment of inflammatory cells	780: Increase, Cytotoxicity (epithelial cells)	May 25, 2022	May 25, 2022	1 AOP 451: Interaction with lung resident cell membrane components leads to lung cancer
2761	1497: Recruitment of inflammatory cells	1496: Increased proinflammatory mediators	Sep 1, 2022	Sep 1, 2022	1 AOP 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)

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