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All KERs

Showing 2326 to 2350 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3414	584: Inhibition, sodium channel	698: Altered, Action Potential	Nov 21, 2024	Nov 21, 2024	1 AOP 553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
867	845: Inhibition, UROD	844: Oxidation, Uroporphyrinogen	Nov 29, 2016	Nov 29, 2016	None
1070	845: Inhibition, UROD	846: Accumulation, Highly carboxylated porphyrins	Nov 29, 2016	May 30, 2018	1 AOP 131: Aryl hydrocarbon receptor activation leading to uroporphyria
335	305: Inhibition, VegfR2	28: Reduction, Angiogenesis	Nov 29, 2016	Jul 20, 2022	1 AOP 43: Disruption of VEGFR Signaling Leading to Developmental Defects
1382	1294: Inhibition, Wnt pathway	1295: Defect of Embryogenesis	Feb 15, 2017	Feb 15, 2017	1 AOP 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
3331	2255: Activation of the innate immune response	272: Activation/Proliferation, T-cells	Aug 13, 2024	Aug 13, 2024	None
3341	2255: Activation of the innate immune response	2260: Activation of gluten-reactive CD4+ T cells	Sep 13, 2024	Jun 17, 2025	1 AOP 524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
2702	2037: Activation, IP3R	389: Increased, Intracellular Calcium overload	Jul 25, 2022	Jul 25, 2022	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
3037	2037: Activation, IP3R	1350: Increased, glutamate	Sep 8, 2023	Sep 8, 2023	1 AOP 490: Co-activation of IP3R and RyR leads to reduced IQ through non-cholinergic mechanisms
329	298: Insufficiency, Vascular	183: Abnormal, Morphogenesis	Nov 29, 2016	Dec 3, 2016	None
1036	298: Insufficiency, Vascular	1001: Increased, Developmental Defects	Nov 29, 2016	Jan 18, 2022	1 AOP 43: Disruption of VEGFR Signaling Leading to Developmental Defects
3178	2119: Insulin resistance, increased	2129: Metabolically unhealthy Obesity	Apr 9, 2024	Apr 9, 2024	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
3180	2119: Insulin resistance, increased	2145: Metabolic syndrome	Apr 9, 2024	Apr 9, 2024	1 AOP 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
1836	1584: Interaction of α-diketones with arginine residues	1585: Proteasomal dysfunction	Jan 30, 2019	Jan 30, 2019	1 AOP 280: α-diketone-induced bronchiolitis obliterans
1017	979: Interference, nuclear localization of NFAT	981: Reduction, NFAT/AP-1 complex formation	Nov 29, 2016	Jul 2, 2021	1 AOP 154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
2497	1901: IFN-I response, antagonized	1847: SARS-CoV-2 production	Oct 24, 2021	Dec 14, 2023	5 AOPs 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
1118	1074: interruption, Ovulation	1076: Increased, circulating estrogen levels	Nov 29, 2016	Dec 3, 2016	1 AOP 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
2490	1931: Disruption of the intestinal barrier	1497: Recruitment of inflammatory cells	Oct 19, 2021	Oct 19, 2021	None
2494	1931: Disruption of the intestinal barrier	1932: GI disorders	Oct 19, 2021	Oct 19, 2021	None
2495	1931: Disruption of the intestinal barrier	1868: Hyperinflammation	Oct 19, 2021	Feb 8, 2023	None
3335	1931: Disruption of the intestinal barrier	2257: Celiac disease	Aug 13, 2024	Feb 27, 2025	1 AOP 524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
1167	1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle	1131: Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carbo	Nov 29, 2016	Dec 3, 2016	1 AOP 187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1774	1434: Irritation induced sneezing	1223: Increased Airway Hyper-responsiveness,Cough, Dyspnea	Sep 24, 2018	Sep 24, 2018	None
955	927: S-Glutathionylation, eNOS	932: Uncoupling, eNOS	Nov 29, 2016	Oct 12, 2017	1 AOP 149: Peptide Oxidation Leading to Hypertension
952	935: Decrease, GTPCH-1	934: Decrease, Tetrahydrobiopterin	Nov 29, 2016	Oct 12, 2017	1 AOP 149: Peptide Oxidation Leading to Hypertension

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