Prototypical Stressors

Showing 801 to 825 of 848 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

70	Troglitazone	Troglitazone, CAS-RN: 97322-87-7, DTXSID8023719	163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
416	Tunicamycin	Tunicamycin, CAS-RN: 11089-65-9, DTXSID8036730	None
477	TWS119	TWS119, CAS-RN: 601514-19-6, DTXSID00429550	None
123	Tylenol		None
274	Ultraviolet B radiation		9 AOPs 331: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 327: Excessive reactive oxygen species production leading to mortality (1) 328: Excessive reactive oxygen species production leading to mortality (2) 329: Excessive reactive oxygen species production leading to mortality (3) 330: Excessive reactive oxygen species production leading to mortality (4) 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 388: Deposition of ionising energy leading to population decline via programmed cell death 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction
629	unmethylated CpG motifs (DNA;RNA;ODN)		377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
664	Uranium	Uranium, CAS-RN: 7440-61-1, DTXSID1042522	2 AOPs 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
738	Uranium, soluble salts	Uranium, soluble salts, CAS-RN: NOCAS, DTXSID7024374	447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
539	Urethane	Urethane, CAS-RN: 51-79-6, DTXSID9021427	None
253	UV-activated Titanium dioxide nanoparticles		208: Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure
784	UV-B and UV-C		550: Increased LMNA gene mutation leading to heart failure
97	Valproate		212: Histone deacetylase inhibition leading to testicular atrophy
401	Valproic acid	Valproic acid, CAS-RN: 99-66-1, DTXSID6023733	274: Histone deacetylase inhibition leads to impeded craniofacial development
330	Vancomycin	Vancomycin, CAS-RN: 1404-90-6, DTXSID0042664	257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
55	Vatalanib	Vatalanib, CAS-RN: 212141-54-3, DTXSID2046919 Sunitinib malate, CAS-RN: 341031-54-7, DTXSID4046492	43: Disruption of VEGFR Signaling Leading to Developmental Defects
118	Verapamil	(+/-)-Verapamil, CAS-RN: 52-53-9, DTXSID9041152	2 AOPs 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
686	Vernolate	Vernolate, CAS-RN: 1929-77-7, DTXSID7024376	None
469	Vinblastine sulfate	Vinrosidine sulfate (1:x), CAS-RN: 18556-44-0, DTXSID7047853	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
136	Vinclozalin		None
556	Vinclozolin	Vinclozolin, CAS-RN: 50471-44-8, DTXSID4022361	3 AOPs 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring
131	Vincristine	Vincristine, CAS-RN: 57-22-7, DTXSID1032278	None
153	Vinyl acetate	Vinyl acetate, CAS-RN: 108-05-4, DTXSID3021431	136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
378	Virus		2 AOPs 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis
746	Vismodegib	Vismodegib, CAS-RN: 879085-55-9, DTXSID40236689	460: Antagonism of Smoothened receptor leading to orofacial clefting
732	Vitamin A		436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries