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Showing 326 to 350 of 548 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
385 Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation Brendan Ferreri-Hanberry BY-SA 1739: Binding to ACE2 None
386 Deposition of ionizing energy leading to population decline via inhibition of photosynthesis Arthur Author BY-SA 1686: Deposition of Energy
387 Deposition of ionising energy leading to population decline via mitochondrial dysfunction Agnes Aggy BY-SA 1686: Deposition of Energy
388 Deposition of ionising energy leading to population decline via programmed cell death Allie Always BY-SA 1686: Deposition of Energy
389 Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis Evgeniia Kazymova BY-SA 1865: Increase, Oxygen-evolving complex damage
392 Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation Cataia Ives BY-SA 1868: Hyperinflammation Under Development 1.96
393 AOP for thyroid disorder caused by triphenyl phosphate via TRĪ² activation Brendan Ferreri-Hanberry BY-SA 1158: Increased, Hepatic thyroid hormone uptake/transport None
394 SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) Arthur Author BY-SA 1739: Binding to ACE2 1873: impaired olfactory function (anosmia) Under Development 1.96
395 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) Agnes Aggy BY-SA 1739: Binding to ACE2 1875: Cerebrovascular disease (stroke) Under Development 1.96
396 Deposition of ionizing energy leads to population decline via impaired meiosis Allie Always All rights reserved 1550: Deposition of Ionizing Energy
397 Bulky DNA adducts leading to mutations Evgeniia Kazymova BY-SA 1879: Bulky DNA adducts, increase 185: Increase, Mutations Under Development 1.11
398 Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia Cataia Ives BY-SA 1880: Decreased, ALDH1A (RALDH) enzyme activity 406: decreased, Fertility Under Development 1.97
399 Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) Brendan Ferreri-Hanberry BY-SA 1884: Inhibition of Fyna
400 Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males Arthur Author BY-SA 1888: Increased (ectopic) all-trans retinoic acid concentration 1757: Reduce, Sperm count
401 G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects Agnes Aggy BY-SA 2029: protein-coupled estrogen receptor 1 (GPER) activation 1489: N/A, Steatohepatisis
402 Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain Allie Always BY-SA 279: Thyroperoxidase, Inhibition
403 combined unhealthy lifestyle factors leading to metabolic syndrome Evgeniia Kazymova BY-SA None None
404 Metabolic Syndrome leading to Toll Like Receptor dysregulation Cataia Ives BY-SA None None
405 Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function Brendan Ferreri-Hanberry BY-SA 12: Acetylcholinesterase (AchE) Inhibition 402: Cognitive function, decreased
406 SARS-CoV-2 infection leading to hyperinflammation Arthur Author All rights reserved 1739: Binding to ACE2 1868: Hyperinflammation
407 SARS-CoV-2 infection leading to pyroptosis Agnes Aggy All rights reserved 1739: Binding to ACE2 1967: Pyroptosis
408 Imbalance in redox homeostasis leading to structural damage to tissues Allie Always BY-SA None None
409 Frustrated phagocytosis leads to malignant mesothelioma Evgeniia Kazymova BY-SA 1668: Frustrated phagocytosis 1090: Increased, mesotheliomas
410 GSK3beta inactivation leading to increased mortality via defects in developing inner ear Cataia Ives BY-SA 1647: GSK3beta inactivation
411 Oxidative stress Leading to Decreased Lung Function Brendan Ferreri-Hanberry BY-SA 1392: Oxidative Stress 1250: Decrease, Lung function