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Showing 376 to 400 of 548 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
437 Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity Agnes Aggy BY-SA 105: Inhibition, Mitochondrial Electron Transport Chain Complexes 814: Occurrence, Kidney toxicity Under Development 1.99
438 reactive oxygen species generation leading to increased cardiovascular morbidity and mortality Allie Always All rights reserved None None
439 Activation of the AhR leading to metastatic breast cancer Evgeniia Kazymova BY-SA 18: Activation, AhR 1982: metastatic breast cancer Under Review 1.105
440 Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia Cataia Ives All rights reserved 1046: Suppression, Estrogen receptor (ER) activity Under Development 1.104
441 Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation Brendan Ferreri-Hanberry BY-SA 1686: Deposition of Energy 1978: Increase risk, microcephaly
442 Binding to voltage gate sodium channels during development leads to cognitive impairment Arthur Author BY-SA 1353: Binding to voltage-gated sodium channel 402: Cognitive function, decreased WPHA/WNT Endorsed 1.91
443 DNA damage and mutations leading to Metastatic Breast Cancer Agnes Aggy BY-SA 1669: Increased, DNA damage and mutation 1982: metastatic breast cancer Under Development 1.103
444 Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability Allie Always BY-SA 360: Decrease, Population growth rate
445 Estrogen Receptor Alpha Agonism leads to Impaired Reproduction Evgeniia Kazymova BY-SA 1065: Activation, estrogen receptor alpha 1991: Impaired, Reproduction
446 PM-related Adverse outcome pathway frameworks on various systems Cataia Ives BY-SA None None
447 Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways Brendan Ferreri-Hanberry BY-SA None 759: Increased, Kidney Failure
448 ROS, inflammation, and activation of nAChR lead to increased incidence of cardiovascular morbidity and mortality Arthur Author BY-SA None None
449 Ceramide synthase inhibition leading to neural tube defects Agnes Aggy BY-SA 2023: Inhibition of Ceramide Synthase 1561: Neural tube defects
450 Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality Allie Always BY-SA 12: Acetylcholinesterase (AchE) Inhibition
451 Interaction with lung resident cell membrane components leads to lung cancer Evgeniia Kazymova BY-SA 1495: Substance interaction with the lung resident cell membrane components 1670: Lung cancer
452 Adverse outcome pathway of PM-induced respiratory toxicity Cataia Ives BY-SA 2007: Non-coding RNA expression profile alteration 2008: Chronic obstructive pulmonary disease
453 Reactive oxygen species and subsequent oxidative stress lead to increased incidence of digestive morbidity and mortality in the general population Brendan Ferreri-Hanberry BY-SA None None
454 PM2.5-related AOP frameworks on liver diseases Arthur Author BY-SA None None
455 Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development Agnes Aggy BY-SA 18: Activation, AhR WPHA/WNT Endorsed 1.27
456 Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity Allie Always BY-SA 18: Activation, AhR 947: Increase, Early Life Stage Mortality WPHA/WNT Endorsed 1.27
457 Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine Evgeniia Kazymova Open for adoption 2118: Succinate dehydrogenase, inhibited 2119: Insulin resistance, increased
458 AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals Cataia Ives Open for adoption 18: Activation, AhR 402: Cognitive function, decreased
459 AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals Brendan Ferreri-Hanberry Open for adoption 18: Activation, AhR 402: Cognitive function, decreased
460 Antagonism of Smoothened receptor leading to orofacial clefting Arthur Author All rights reserved 2027: Antagonism, Smoothened receptor 2042: Increase, Orofacial clefting Under Review 1.101
461 Deposition of ionising energy leads to population decline via impaired oogenesis and spermatogenesis Agnes Aggy BY-SA None None