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Showing 501 to 525 of 548 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
563 Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis Arthur Author All rights reserved 18: Activation, AhR 2305: Premature ovarian Insufficiency
564 DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. Agnes Aggy BY-SA 1541: Mitochondrial Complex I inhibition
565 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha Allie Always All rights reserved 2250: 17β-Hydroxysteroid dehydrogenase 2, inhibition None
566 Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation Evgeniia Kazymova All rights reserved None 2306: Persistent vaginal cornification
567 Binding of plastoquinone B leading to decrease, population growth rate via decrease, photosystem II efficiency Cataia Ives BY-SA 2307: Binding of plastoquinone B 360: Decrease, Population growth rate
568 Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding Brendan Ferreri-Hanberry BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1016: Inhibition, Feeding
569 Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway Arthur Author All rights reserved 2309: Decreased DNA methylation of FAM50B/PTCHD3 2121: decreased, Intellectual Quotient
570 Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring Agnes Aggy BY-SA None 2082: Hypospadias, increased
571 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring Allie Always BY-SA 1617: Inhibition, 5α-reductase 2082: Hypospadias, increased
572 BMP4 Suppression Disrupting Cytoskeletal Remodeling Leading to Neural Tube Closure Defects Evgeniia Kazymova All rights reserved None None
573 Inhibition, cytochrome oxidase leads to Increased, pulmonary edema Cataia Ives BY-SA 1840: Inhibition, cytochrome oxidase 2316: Increased, pulmonary edema
574 Inhibition, cytochrome oxidase leads to Loss of olfactory function Brendan Ferreri-Hanberry BY-SA 1840: Inhibition, cytochrome oxidase 2317: Loss of olfactory function
575 Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring Arthur Author BY-SA None 1786: Nipple retention (NR), increased
576 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring Agnes Aggy BY-SA 1617: Inhibition, 5α-reductase 1786: Nipple retention (NR), increased
577 AhR activation leading to endometriosis Allie Always BY-SA 18: Activation, AhR None
578 AhR activation leading to cancer progression via immunosuppression Evgeniia Kazymova BY-SA 18: Activation, AhR 1971: Increased, tumor growth
579 Transthyretin disruption in developing fish leading to projected decline in fish population Cataia Ives BY-SA None None
580 Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index Brendan Ferreri-Hanberry All rights reserved 2331: Activation, Mineralocorticoid Receptor 2335: Increase, body mass index
581 Glucocorticoid receptor (GR) activation leads to cognitive function (COG) decrease Arthur Author All rights reserved 122: Activation, Glucocorticoid Receptor 402: Cognitive function, decreased
582 Inhibition of EphA2 phosphorylation leads to liver damage via the ERK/ MDM2/p53 axis Agnes Aggy All rights reserved None None
583 Vascular endothelial HER2 inhibition disrupts cardiomyocyte calcium homeostasis via EGFR/STAT3/PTX3 axis leading to cardiac contractile dysfunction Allie Always All rights reserved None None
584 SQLE accumulation leads to hepatotoxicity via cholesterol/sphingolipid metabolic disturbance and lysosomal damage Evgeniia Kazymova All rights reserved None None
585 AKT Inhibition blocks the autophagy flow through the PRKAA/AMPK pathway and leads to cardiotoxicity Cataia Ives All rights reserved None None
586 The increasing accumulation of HMGB1 in the nucleus causes cardiomyocyte death via HMGB1/HSPB1/CCN2 pathway Brendan Ferreri-Hanberry All rights reserved None None
587 Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits Arthur Author BY-SA 1542: Inhibition, Mitochondrial complex III 896: Parkinsonian motor deficits