| 2803 |
2074: Decrease overall oxygen binding capacity (methemocyanin formation) |
2076: Increase, hemocyanin mRNA |
Nov 16, 2022 |
Nov 16, 2022 |
1 AOP
|
| 1433 |
1324: Decreased, packaged serotonin |
1325: Decreased, synaptic release |
Apr 14, 2017 |
Apr 14, 2017 |
4 AOPs
|
| 503 |
216: Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) |
327: Accumulation, Fatty acid |
Nov 29, 2016 |
Dec 3, 2016 |
1 AOP
|
| 881 |
859: Decreased, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids |
860: Decreased, Mitochondrial Fatty Acid Beta Oxidation |
Nov 29, 2016 |
Nov 29, 2016 |
None
|
| 3289 |
2237: Decreased, Plasma sodium concentrations |
1768: Increase, Abnormal osmoregulation |
Jul 8, 2024 |
Dec 3, 2024 |
None
|
| 3346 |
2237: Decreased, Plasma sodium concentrations |
2261: Decreased, blood plasma volume |
Sep 20, 2024 |
Dec 3, 2024 |
1 AOP
|
| 1491 |
442: Decreased, Population trajectory |
351: Increased Mortality |
Apr 18, 2017 |
Apr 18, 2017 |
None
|
| 257 |
231: Decreased, PPAR-alpha activation |
140: Decreased, HSD17B10 expression |
Nov 29, 2016 |
Dec 3, 2016 |
1 AOP
|
| 2042 |
231: Decreased, PPAR-alpha activation |
459: Increased, Liver Steatosis |
Feb 22, 2020 |
Feb 22, 2020 |
None
|
| 259 |
232: Decreased, PPAR-beta activation |
140: Decreased, HSD17B10 expression |
Nov 29, 2016 |
Dec 3, 2016 |
1 AOP
|
| 260 |
233: Decreased, PPAR-gamma activation |
140: Decreased, HSD17B10 expression |
Nov 29, 2016 |
Dec 3, 2016 |
1 AOP
|
| 3093 |
233: Decreased, PPAR-gamma activation |
1060: Alteration, lipid metabolism |
Oct 18, 2023 |
Oct 19, 2023 |
1 AOP
|
| 878 |
858: Decreased, PPARalpha transactivation of gene expression |
859: Decreased, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids |
Nov 29, 2016 |
Jun 2, 2017 |
None
|
| 879 |
858: Decreased, PPARalpha transactivation of gene expression |
860: Decreased, Mitochondrial Fatty Acid Beta Oxidation |
Nov 29, 2016 |
Jun 2, 2017 |
None
|
| 880 |
858: Decreased, PPARalpha transactivation of gene expression |
861: Decreased, Ketogenesis (production of ketone bodies) |
Nov 29, 2016 |
Jun 11, 2018 |
1 AOP
|
| 1748 |
858: Decreased, PPARalpha transactivation of gene expression |
1528: Fatty Acid Beta Oxidation, Decreased |
Jun 11, 2018 |
Jun 11, 2018 |
1 AOP
|
| 3520 |
2319: Decreased, Pregnenolone levels |
1610: Reduction, DHEA |
Apr 8, 2025 |
Apr 8, 2025 |
None
|
| 3522 |
2319: Decreased, Pregnenolone levels |
1693: Decreased, Progesterone levels |
Apr 8, 2025 |
Apr 8, 2025 |
None
|
| 772 |
749: Decreased, Progesterone from corpus luteum |
772: Increase, Hyperplasia (glandular epithelial cells of endometrium) |
Nov 29, 2016 |
Dec 3, 2016 |
1 AOP
|
| 1988 |
1693: Decreased, Progesterone levels |
1694: Reduction, progesterone uptake, decresed maturation |
Oct 3, 2019 |
Oct 3, 2019 |
1 AOP
|
| 3521 |
1693: Decreased, Progesterone levels |
1611: Reduction, androstenedione |
Apr 8, 2025 |
Apr 8, 2025 |
None
|
| 3524 |
747: Decreased, Prolactin |
111: Agonism, Estrogen receptor |
Apr 17, 2025 |
Apr 17, 2025 |
1 AOP
|
| 1138 |
1104: Decreased, Prostaglandin F2alpha concentration, plasma |
1105: Occurrence, renal ischemia |
Nov 29, 2016 |
Dec 3, 2016 |
1 AOP
|
| 682 |
681: Decreased, Prostaglandin F2alpha synthesis, ovary |
671: Reduced, Prostaglandin F2alpha concentration, plasma |
Nov 29, 2016 |
Dec 3, 2016 |
1 AOP
|
| 3647 |
968: Decreased, release of kisspeptin from AVPV neurons |
530: Decreased, GnRH pulsatility/release |
Oct 2, 2025 |
Oct 2, 2025 |
1 AOP
|