Key Event Relationships (KERs)

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Showing 1201 to 1225 of 3002 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1289 1236: Generation of novel epitopes , Antigen presentation 1237: Sensitization, Immune system Nov 29, 2016 Dec 3, 2016 None
684 682: Generation, Amplified excitatory postsynaptic potential (EPSP) 616: Occurrence, A paroxysmal depolarizing shift Nov 29, 2016 May 15, 2018
2418 1896: Genomic instability 870: Increase, Cell Proliferation Jul 6, 2021 Jul 6, 2021
2973 1896: Genomic instability 2154: endometrioid adenocarcinoma Type I Jul 27, 2023 Mar 27, 2025
1645 494: GR Agonist, Activation 496: Decreased Leydig Cells Aug 11, 2017 Aug 11, 2017
1646 494: GR Agonist, Activation 495: Repressed expression of steroidogenic enzymes Aug 11, 2017 Aug 11, 2017
1686 1488: Glutamate dyshomeostasis 55: Cell injury/death Nov 9, 2017 Feb 6, 2020
1691 1488: Glutamate dyshomeostasis 386: Neuronal network function, Decreased Nov 9, 2017 Nov 9, 2017 None
1378 1290: Glutathione homeostasis 1291: Hepatotoxicity Feb 15, 2017 Feb 15, 2017
1374 1287: Glutathione synthesis 1288: Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene Feb 15, 2017 Feb 15, 2017
3386 2275: Co-localization of gluten reactive adaptive T-cells with APC 2255: Activation of the innate immune response Nov 12, 2024 Jun 17, 2025
3387 2275: Co-localization of gluten reactive adaptive T-cells with APC 2252: Formation of HLA-DQ2/8-gluten complexes Nov 12, 2024 Nov 12, 2024 None
3330 2254: Generation of gluten-reactive and TG2-reactive B cell receptors 272: Activation/Proliferation, T-cells Aug 13, 2024 Aug 13, 2024 None
3340 2254: Generation of gluten-reactive and TG2-reactive B cell receptors 2260: Activation of gluten-reactive CD4+ T cells Sep 13, 2024 Sep 13, 2024 None
3384 2254: Generation of gluten-reactive and TG2-reactive B cell receptors 2275: Co-localization of gluten reactive adaptive T-cells with APC Nov 12, 2024 Feb 27, 2025
3333 2256: Activation of gluten- and TG2-reactive B cells 1931: Disruption of the intestinal barrier Aug 13, 2024 Apr 27, 2025
3336 2256: Activation of gluten- and TG2-reactive B cells 272: Activation/Proliferation, T-cells Aug 13, 2024 Aug 13, 2024 None
3345 2256: Activation of gluten- and TG2-reactive B cells 2260: Activation of gluten-reactive CD4+ T cells Sep 13, 2024 Sep 13, 2024 None
3342 2260: Activation of gluten-reactive CD4+ T cells 2256: Activation of gluten- and TG2-reactive B cells Sep 13, 2024 Feb 27, 2025
3343 2260: Activation of gluten-reactive CD4+ T cells 1931: Disruption of the intestinal barrier Sep 13, 2024 Sep 13, 2024 None
3344 2260: Activation of gluten-reactive CD4+ T cells 2252: Formation of HLA-DQ2/8-gluten complexes Sep 13, 2024 Sep 13, 2024 None
3329 2253: Generation of gluten-reactive T cell receptors 272: Activation/Proliferation, T-cells Aug 13, 2024 Aug 13, 2024 None
3339 2253: Generation of gluten-reactive T cell receptors 2260: Activation of gluten-reactive CD4+ T cells Sep 13, 2024 Sep 13, 2024 None
3385 2253: Generation of gluten-reactive T cell receptors 2275: Co-localization of gluten reactive adaptive T-cells with APC Nov 12, 2024 Apr 8, 2025
3142 1800: Reduced granulosa cell proliferation 405: disrupted, ovarian cycle Mar 7, 2024 Mar 18, 2025