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Showing 1326 to 1350 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3622	1758: Impaired, Spermatogenesis	1863: Decrease, Reproduction	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Nanoplastic effect
665	583: impaired, Thoracic shivering	568: impaired, Hive thermoregulation	Nov 29, 2016	Dec 3, 2016	None
3173	2213: Impaired, urethral tube closure	2082: Hypospadias	Mar 20, 2024	Dec 3, 2024	1 AOP 527: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased
125	110: Impairment, Endothelial network	298: Insufficiency, Vascular	Nov 29, 2016	Jan 18, 2022	1 AOP 43: Disruption of VEGFR Signaling Leading to Developmental Defects
976	110: Impairment, Endothelial network	317: Altered, Cardiovascular development/function	Nov 29, 2016	Jun 9, 2017	1 AOP 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
564	341: Impairment, Learning and memory	564: Abnormal, Roll change within caste	Nov 29, 2016	Dec 3, 2016	2 AOPs 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
583	341: Impairment, Learning and memory	560: Abnormal, Foraging activity and behavior	Nov 29, 2016	Dec 3, 2016	4 AOPs 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
1644	341: Impairment, Learning and memory	635: Decreased, locomotion	Aug 11, 2017	Aug 11, 2017	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
2872	341: Impairment, Learning and memory	2121: decreased, IQ	Apr 4, 2023	Apr 4, 2023	1 AOP 490: Co-activation of IP3R and RyR leads to reduced IQ through non-cholinergic mechanisms
1446	1328: Inactivated, 5-HTR	1329: Reduce expression, BDNF	Apr 14, 2017	Apr 14, 2017	3 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 225: Serotonin transporter activation to agitation 224: Serotonin transporter activation to depression
1511	1328: Inactivated, 5-HTR	1335: Reduced, BDNF	May 30, 2017	May 30, 2017	1 AOP 222: Mental stress to agitation
1353	1270: Inactivation of PPARγ	1271: Activation of TGF-β signaling	Feb 15, 2017	Feb 15, 2017	1 AOP 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
2156	1270: Inactivation of PPARγ	1283: Activation, TGF-beta pathway	Jul 9, 2020	Jul 9, 2020	1 AOP 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
164	155: Inadequate DNA repair	185: Increase, Mutations	Nov 29, 2016	Mar 8, 2024	8 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 141: Alkylation of DNA leading to cancer 2 139: Alkylation of DNA leading to cancer 1 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 397: Bulky DNA adducts leading to mutations 443: DNA damage and mutations leading to Metastatic Breast Cancer 478: Deposition of energy leading to occurrence of cataracts
1910	155: Inadequate DNA repair	1635: Increase, DNA strand breaks	May 19, 2019	Jan 9, 2023	3 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 322: Alkylation of DNA leading to reduced sperm count 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage
1912	155: Inadequate DNA repair	1636: Increase, Chromosomal aberrations	May 19, 2019	Dec 17, 2024	3 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 478: Deposition of energy leading to occurrence of cataracts
2817	155: Inadequate DNA repair	2083: Cataracts	Dec 18, 2022	Mar 11, 2024	1 AOP 478: Deposition of energy leading to occurrence of cataracts
1793	1552: DNA repair	1553: Increase mutations	Dec 19, 2018	Dec 19, 2018	None
1794	1552: DNA repair	1554: Increase chromosomal aberrations	Dec 19, 2018	Dec 19, 2018	None
1797	1555: Increase cell proliferation	1556: Increase, lung cancer	Dec 19, 2018	Dec 19, 2018	None
1796	1554: Increase chromosomal aberrations	1555: Increase cell proliferation	Dec 19, 2018	Dec 19, 2018	None
1801	1554: Increase chromosomal aberrations	1556: Increase, lung cancer	Dec 19, 2018	Dec 19, 2018	None
2729	1554: Increase chromosomal aberrations	1980: Increase,miRNA levels	Aug 14, 2022	Aug 27, 2023	1 AOP 443: DNA damage and mutations leading to Metastatic Breast Cancer
2199	1633: Increase in inflammation	1820: hepatitis	Nov 2, 2020	Nov 2, 2020	1 AOP 362: Immune mediated hepatitis
2646	1633: Increase in inflammation	1097: Occurrence, renal proximal tubular necrosis	Apr 8, 2022	Apr 8, 2022	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways

Key Event Relationships (KERs)

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