AOP-Wiki

API

All KERs

Showing 2401 to 2425 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1684	177: Mitochondrial dysfunction	1392: Oxidative Stress	Nov 9, 2017	Nov 9, 2017	2 AOPs 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
2228	177: Mitochondrial dysfunction	1771: Decrease, ATP pool	Dec 4, 2020	Dec 4, 2020	None
2822	177: Mitochondrial dysfunction	40: Decrease, Mitochondrial ATP production	Jan 5, 2023	Jan 5, 2023	2 AOPs 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production 258: Renal protein alkylation leading to kidney toxicity
3131	177: Mitochondrial dysfunction	1365: Increase, Apoptosis	Feb 21, 2024	Feb 21, 2024	2 AOPs 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
3132	177: Mitochondrial dysfunction	1928: increased，Vascular endothelial dysfunction	Feb 21, 2024	Feb 21, 2024	2 AOPs 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3134	177: Mitochondrial dysfunction	709: Increase, Cytotoxicity (renal tubular cell)	Feb 28, 2024	Mar 6, 2024	2 AOPs 256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity
3136	177: Mitochondrial dysfunction	1585: Proteasomal dysfunction	Feb 29, 2024	Feb 29, 2024	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
3141	177: Mitochondrial dysfunction	1115: Increase, ROS	Mar 6, 2024	Apr 11, 2024	2 AOPs 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 273: Mitochondrial complex inhibition leading to liver injury
3146	177: Mitochondrial dysfunction	1262: Apoptosis	Mar 13, 2024	Mar 13, 2024	3 AOPs 205: AOP from chemical insult to cell death 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans 595: Nanoplastic effect
3149	177: Mitochondrial dysfunction	1263: Necrosis	Mar 13, 2024	Mar 13, 2024	1 AOP 205: AOP from chemical insult to cell death
3150	177: Mitochondrial dysfunction	1762: cell injury	Mar 13, 2024	Mar 13, 2024	1 AOP 335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
3152	177: Mitochondrial dysfunction	1817: Apoptotic cell death	Mar 13, 2024	Mar 13, 2024	1 AOP 362: Immune mediated hepatitis
3153	177: Mitochondrial dysfunction	1815: ER stress	Mar 13, 2024	Mar 13, 2024	1 AOP 362: Immune mediated hepatitis
3155	177: Mitochondrial dysfunction	833: Occurrence, Cytoplasmic vacuolization (hepatocyte)	Mar 13, 2024	Mar 13, 2024	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
3156	177: Mitochondrial dysfunction	835: Occurrence, Ballooning degeneration (hepatocyte)	Mar 13, 2024	Mar 13, 2024	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
3157	177: Mitochondrial dysfunction	837: Occurrence, Cytoplasmic vacuolization (kupffer cell)	Mar 13, 2024	Mar 13, 2024	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
3158	177: Mitochondrial dysfunction	836: Occurrence, Cytoplasmic vacuolization (Bile duct cell)	Mar 13, 2024	Mar 13, 2024	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
3161	177: Mitochondrial dysfunction	2144: Impaired insulin signaling	Mar 13, 2024	Mar 13, 2024	1 AOP 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
3164	177: Mitochondrial dysfunction	1917: Altered expression of NRF2 pathway-dependent genes	Mar 14, 2024	Mar 14, 2024	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
3165	177: Mitochondrial dysfunction	202: Inhibition, Nuclear factor kappa B (NF-kB)	Mar 14, 2024	Mar 14, 2024	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
2193	1816: Mitochondrial dysfunction EMPTY	1817: Apoptotic cell death	Nov 2, 2020	Nov 2, 2020	None
2195	1816: Mitochondrial dysfunction EMPTY	1815: ER stress	Nov 2, 2020	Nov 2, 2020	None
2499	1816: Mitochondrial dysfunction EMPTY	1392: Oxidative Stress	Oct 26, 2021	Oct 26, 2021	1 AOP 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
2932	1816: Mitochondrial dysfunction EMPTY	2144: Impaired insulin signaling	May 25, 2023	May 25, 2023	None
3043	1816: Mitochondrial dysfunction EMPTY	1585: Proteasomal dysfunction	Sep 14, 2023	Sep 14, 2023	None

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