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All KERs

Showing 201 to 225 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

986	941: Activation, EGFR	962: Increase, Mucin production	Nov 29, 2016	Mar 9, 2023	1 AOP 148: EGFR Activation Leading to Decreased Lung Function
2469	941: Activation, EGFR	920: Goblet cell metaplasia	Aug 25, 2021	Aug 27, 2021	None
2857	941: Activation, EGFR	2117: Increase, goblet cell number	Mar 15, 2023	Mar 16, 2023	1 AOP 148: EGFR Activation Leading to Decreased Lung Function
936	913: Activation, Epidermal Growth Factor Receptor	914: Decreased ciliated cell apoptosis	Nov 29, 2016	Dec 3, 2016	None
939	913: Activation, Epidermal Growth Factor Receptor	923: Increased goblet cell proliferation	Nov 29, 2016	Dec 3, 2016	None
942	913: Activation, Epidermal Growth Factor Receptor	919: Occurrence, Transdifferentiation of ciliated epithelial cells	Nov 29, 2016	Nov 29, 2016	None
946	913: Activation, Epidermal Growth Factor Receptor	924: Activation, Sp1	Nov 29, 2016	Dec 3, 2016	None
1103	1065: Activation, ERα	1066: Promotion, SIX1 positive progenitor cells in endometrium	Nov 29, 2016	Dec 3, 2016	None
2665	1065: Activation, ERα	1985: Increased, Kisspeptin signalling	Jun 6, 2022	Aug 15, 2022	1 AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
2666	1065: Activation, ERα	1986: Decreased, Gonadotropins	Jun 6, 2022	Aug 15, 2022	1 AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
2730	1065: Activation, ERα	1991: Impaired, Reproduction	Aug 15, 2022	Aug 15, 2022	1 AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
2969	1065: Activation, ERα	2152: Epigenetic modification process	Jul 27, 2023	Apr 28, 2025	1 AOP 503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
3646	1065: Activation, ERα	968: Decreased, release of kisspeptin from AVPV neurons	Oct 2, 2025	Oct 2, 2025	1 AOP 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
133	116: Activation, FAS	89: Synthesis, De Novo Fatty Acid (FA)	Nov 29, 2016	Dec 3, 2016	1 AOP 34: LXR activation leading to hepatic steatosis
1422	116: Activation, FAS	1306: Increased, lipogenesis	Apr 13, 2017	Apr 13, 2017	None
1381	1293: Activation, FOXO	1294: Inhibition, Wnt pathway	Feb 15, 2017	Feb 15, 2017	1 AOP 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
3590	1293: Activation, FOXO	2347: Increase, Lipid degradation	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBEPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
1407	1304: Activation, FXR	480: Activation, SHP	Apr 12, 2017	Apr 12, 2017	None
1408	1304: Activation, FXR	227: Activation, PPARα	Apr 12, 2017	Apr 12, 2017	None
385	122: Activation, Glucocorticoid Receptor	145: Induction, IKB inhibitory protein	Nov 29, 2016	Dec 3, 2016	1 AOP 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
1451	122: Activation, Glucocorticoid Receptor	1335: Reduced, BDNF	Apr 14, 2017	Apr 14, 2017	1 AOP 214: Network of SSRIs (selective serotonin reuptake inhibitors)
2039	122: Activation, Glucocorticoid Receptor	860: Decreased, Mitochondrial Fatty Acid Beta Oxidation	Feb 22, 2020	Feb 22, 2020	None
2041	122: Activation, Glucocorticoid Receptor	231: Decreased, PPAR-alpha activation	Feb 22, 2020	Feb 22, 2020	None
2261	122: Activation, Glucocorticoid Receptor	54: Up Regulation, CD36	Jan 15, 2021	Jan 15, 2021	None
2266	122: Activation, Glucocorticoid Receptor	1834: Decrease, ACAD	Jan 15, 2021	Jan 15, 2021	1 AOP 318: Glucocorticoid Receptor activation leading to hepatic steatosis

Key Event Relationships (KERs)

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