AOPs

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Showing 401 to 425 of 548 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
462 Activation of reactive oxygen species leading the atherosclerosis Allie Always BY-SA 1115: Increase, Reactive oxygen species None
463 The AOP framwork on silica nanopariticles induced hepatoxicity Evgeniia Kazymova BY-SA None None
464 Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits Cataia Ives All rights reserved 896: Parkinsonian motor deficits
465 Alcohol dehydrogenase leading to reproductive dysfunction Brendan Ferreri-Hanberry BY-SA 2045: Increase, Alcohol dehydrogenase None
466 Doda decarboxylase leading to mortality Arthur Author BY-SA 2051: Decrease, Tyrosine None
467 Knickkopf leading to mortality Agnes Aggy BY-SA 2058: Decrease, 20-hydroxyecdysone None
468 Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) Allie Always BY-SA 1739: Binding to ACE2 1868: Hyperinflammation
469 Reactive oxygen speicies overproduction leading to increased digestive morbidity and mortality in generation population Evgeniia Kazymova BY-SA None None
470 Deposition of energy leads to abnormal vascular remodeling Cataia Ives BY-SA 1686: Deposition of Energy 2069: Occurrence, Abnormal Vascular Remodeling WPHA/WNT Endorsed 1.89
471 Various neuronal effects induced by elavl3, sox10, and mbp Brendan Ferreri-Hanberry BY-SA 2195: Increase, CNS Neural cell death
472 DNA adduct formation leading to kidney failure Arthur Author BY-SA None None
473 Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin Agnes Aggy BY-SA 1686: Deposition of Energy
474 Succinate dehydrogenase inactivation leads to cancer by promoting EMT Allie Always BY-SA 2118: Succinate dehydrogenase, inhibited 885: Increase, Cancer Under Development 1.106
475 Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons Evgeniia Kazymova All rights reserved 875: Binding of agonist, Ionotropic glutamate receptors 341: Impairment, Learning and memory Under Development 1.107
476 Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity Cataia Ives All rights reserved
477 Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring Brendan Ferreri-Hanberry BY-SA 26: Antagonism, Androgen receptor 2082: Hypospadias, increased
478 Deposition of energy leading to occurrence of cataracts Arthur Author BY-SA 1686: Deposition of Energy 2083: Occurrence of Cataracts WPHA/WNT Endorsed 1.89
479 Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress Agnes Aggy BY-SA 105: Inhibition, Mitochondrial Electron Transport Chain Complexes 2215: Decrease Left Ventricular function Under Development 1.102
480 Mitochondrial complexes inhibition leading to heart failure via decreased ATP production Allie Always BY-SA 105: Inhibition, Mitochondrial Electron Transport Chain Complexes 2215: Decrease Left Ventricular function Under Development 1.102
481 AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases. Evgeniia Kazymova BY-SA 1115: Increase, Reactive oxygen species
482 Deposition of energy leading to occurrence of bone loss Cataia Ives BY-SA 1686: Deposition of Energy 2091: Occurrence, Bone Loss WPHA/WNT Endorsed 1.89
483 Deposition of Energy Leading to Learning and Memory Impairment Brendan Ferreri-Hanberry BY-SA 1686: Deposition of Energy 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.89
484 Bisphenol A analogs induce cellular dysfunction in human trophoblast cells in a thyroid hormone receptor-dependent manner: in silico and in vitro analyses Arthur Author BY-SA None None
485 Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition Agnes Aggy BY-SA 1656: Antagonism, Thyroid Receptor 402: Cognitive function, decreased
486 Binding to the extracellular protein laminin leading to decreased cognitive function Allie Always BY-SA 2109: Binding, extracellular matrix protein laminin 402: Cognitive function, decreased