Immunotoxicity AOPs

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AOP Collection · Submitted · Created by Alexandra Schaffert

Purpose
AOPs related to an adverse alteration of immune system function or integrity caused by a stressor, resulting in impaired immune defense, inappropriate immune activation, hypersensitivity, autoimmunity, or disrupted immune development.
Creation Strategy
Manual inspection of AOs and AOP titles for: * Immunosuppression * Immune hyperactivation * Increased disease susceptibility * Hypersensitivity * Autoimmunity * Developmental immunotoxicity

AOPs in this Collection (20)

ID Title License OECD Status
14 Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility BY-SA
154 Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response BY-SA WPHA/WNT Endorsed
277 Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response BY-SA WPHA/WNT Endorsed
282 Adverse outcome pathway on photochemical toxicity initiated by light exposure BY-SA Under Review
313 Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease BY-SA Under Development
314 Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) BY-SA Under Development
315 Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response BY-SA Under Development
362 Immune mediated hepatitis BY-SA
377 Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) BY-SA
378 Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load BY-SA
392 Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation BY-SA Under Development
406 SARS-CoV-2 infection leading to hyperinflammation BY-SA
407 SARS-CoV-2 infection leading to pyroptosis BY-SA
412 Endothelial cell dysfunction leading to thromboinflammation BY-SA Under Development
430 Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation BY-SA Under Development
468 Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) BY-SA
506 Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation All rights reserved
524 Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals BY-SA Under Review
578 AhR activation leading to cancer progression via immunosuppression BY-SA
618 PPARgamma activation leads to a diminished vaccine response BY-SA
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