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Showing 1801 to 1825 of 1872 Key Events

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ID Title Event Component Count Biological Organization Created At Last Updated AOPs
2302 Increase, Malformations
0 Population Dec 24, 2024 Jan 20, 2025 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
2303 Increased plasma estradiol to progesterone ratio (estrogen dominance/unopposed estrogen)
0 Organ Jan 3, 2025 Jan 3, 2025 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation
2305 Premature ovarian Insufficiency
1 Organ Jan 12, 2025 May 7, 2025 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
2306 Persistent vaginal cornification
1 Tissue Jan 13, 2025 Jan 13, 2025 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation
2307 Binding of plastoquinone B
0 Molecular Jan 14, 2025 Jan 14, 2025 567: Binding of plastoquinone B leading to decrease, population growth rate via decrease, photosystem II efficiency
2308 Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors
3 Organ Jan 14, 2025 Feb 13, 2025 568: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding
2309 Decreased DNA methylation of FAM50B/PTCHD3
0 Molecular Mar 2, 2025 Mar 2, 2025 569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway
2310 Elevated gene expression of FAM50B/PTCHD3
0 Molecular Mar 2, 2025 Mar 2, 2025 569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway
2311 Inhibition of PI3K-Akt pathway
0 Molecular Mar 2, 2025 Mar 2, 2025 569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway
2312 Increased, nasal lesions
1 Organ Mar 5, 2025 Mar 19, 2025 368: Cytochrome oxidase inhibition leading to increased nasal lesions
2313 Increased, Cardiovascular fibrosis
0 Organ Mar 11, 2025 Mar 11, 2025 None
2314 Increased, Cardiovascular dysfunction
0 Individual Mar 11, 2025 Mar 11, 2025 None
2315 Increased, Incidence of cardiovascular disease
0 Population Mar 11, 2025 Mar 11, 2025 None
2316 Increased, pulmonary edema
1 Organ Mar 12, 2025 Mar 24, 2025 573: Inhibition, cytochrome oxidase leads to Increased, pulmonary edema
2317 Loss of olfactory function
1 Organ Mar 13, 2025 Mar 25, 2025 574: Inhibition, cytochrome oxidase leads to Loss of olfactory function
2318 Decreased 3-beta-HSD activity
0 Tissue Apr 8, 2025 Apr 8, 2025 None
2319 Decreased, Pregnenolone levels
0 Tissue Apr 8, 2025 Apr 8, 2025 None
2320 Decreased, 17-beta-HSD3 activity
0 Molecular Apr 8, 2025 Apr 8, 2025 None
2321 Decreased, CYP11A1 activity
0 Molecular Apr 8, 2025 Apr 8, 2025 None
2323 Over-expression of PD-L1 in cancer cells
0 Molecular May 15, 2025 Sep 30, 2025 578: AhR activation leading to cancer progression via immunosuppression
2324 Dysregulation of Treg/Th17 cell ratio
0 Cellular May 16, 2025 May 19, 2025 578: AhR activation leading to cancer progression via immunosuppression
2325 Decreased number of LT CD8+ cells
0 Cellular May 16, 2025 Jun 11, 2025 None
2326 Lymphocytes T CD8+ cytotoxicity
0 Cellular May 22, 2025 Jul 11, 2025 578: AhR activation leading to cancer progression via immunosuppression
2327 Decrease, Cell growth
0 Cellular May 23, 2025 May 23, 2025
2329 Sine oculis homeobox 1 gene expression, increased
1 Molecular Jul 8, 2025 Sep 11, 2025 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells