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Showing 801 to 825 of 3002 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1810	1477: Decrease, OXPHOS	1562: Decreased Na/K ATPase activity	Dec 20, 2018	Dec 20, 2018	1 AOP 276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome
2095	1477: Decrease, OXPHOS	1771: Decrease, ATP pool	Apr 30, 2020	Apr 30, 2020	1 AOP 328: Excessive reactive oxygen species production leading to mortality (2)
2346	1477: Decrease, OXPHOS	1808: Decrease, ATP synthase activity	Apr 11, 2021	Apr 11, 2021	None
2713	1477: Decrease, OXPHOS	1392: Oxidative Stress	Jul 25, 2022	Jul 25, 2022	None
1667	1475: Decrease, Photosynthesis	1476: Decrease, Glycolysis	Oct 10, 2017	Oct 10, 2017	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
2334	1475: Decrease, Photosynthesis	1472: Decrease, ATP production	Apr 11, 2021	Apr 11, 2021	2 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
2343	1475: Decrease, Photosynthesis	1808: Decrease, ATP synthase activity	Apr 11, 2021	Apr 11, 2021	None
3557	1475: Decrease, Photosynthesis	1545: Decrease in mitochondrial oxidative phosphorylation	Aug 5, 2025	Aug 5, 2025	1 AOP 567: Binding of plastoquinone B leading to decrease, population growth rate via decrease, photosystem II efficiency
3612	1475: Decrease, Photosynthesis	360: Decrease, Population growth rate	Sep 2, 2025	Sep 2, 2025	1 AOP 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
1737	1517: Decrease, PSII activity	1475: Decrease, Photosynthesis	May 24, 2018	May 24, 2018	None
2333	1862: Decrease, Photosystem II efficiency	1475: Decrease, Photosynthesis	Apr 11, 2021	Apr 11, 2021	3 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 567: Binding of plastoquinone B leading to decrease, population growth rate via decrease, photosystem II efficiency
2180	1810: Decrease, ATPase activity	1768: Increase, Abnormal osmoregulation	Nov 2, 2020	Nov 2, 2020	None
2756	2061: Decrease, Prevent chitin degradation by chitinases	2062: Weak, Procuticle protection	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
3585	2346: Downregulation, PCNA	1505: Cell cycle, disrupted	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBEPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
2336	1863: Decrease, Reproduction	360: Decrease, Population growth rate	Apr 11, 2021	Apr 11, 2021	5 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 388: Deposition of ionising energy leading to population decline via programmed cell death 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2556	1863: Decrease, Reproduction	442: Decreased, Population trajectory	Jan 21, 2022	Jan 21, 2022	1 AOP 435: Deposition of ionising energy leads to population decline via pollen abnormal
769	771: Decrease, Serum thyroid hormone (T4/T3)	753: Increase, Thyroid-stimulating hormone (TSH)	Nov 29, 2016	Dec 3, 2016	None
2735	2044: Decrease, SMO relocation	2028: Decrease, GLI1/2 translocation	Aug 23, 2022	Apr 2, 2025	1 AOP 460: Antagonism of Smoothened receptor leading to orofacial clefting
2732	2043: Decrease, SHH second messenger production	1821: Decrease, Cell proliferation	Aug 23, 2022	Apr 3, 2025	2 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
2733	2043: Decrease, SHH second messenger production	1365: Increase, Apoptosis	Aug 23, 2022	Aug 23, 2022	None
2957	2043: Decrease, SHH second messenger production	1262: Apoptosis	Jun 29, 2023	Jun 29, 2023	1 AOP 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
3060	2197: Decrease, sox10	352: N/A, Neurodegeneration	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
2685	2020: Decrease, sox9 expression	1559: Smaller and morphologically distorted facial cartilage structures	Jun 30, 2022	Oct 20, 2022	1 AOP 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
2691	2020: Decrease, sox9 expression	317: Altered, Cardiovascular development/function	Jun 30, 2022	Oct 20, 2022	1 AOP 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
436	266: Decrease, Steroidogenic acute regulatory protein (STAR)	447: Reduction, Cholesterol transport in mitochondria	Nov 29, 2016	Apr 8, 2025	1 AOP 18: PPARα activation in utero leading to impaired fertility in males

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