Key Event Relationships (KERs)

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Showing 1401 to 1425 of 3002 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
3034 1365: Increase, Apoptosis 1928: increased，Vascular endothelial dysfunction Aug 28, 2023 Aug 28, 2023
1484 1372: Increase, bicarbonate 1380: Activate, mucosal defense Apr 17, 2017 Apr 17, 2017
2236 401: Increase, Biliary excretion TH glucuronide 281: T4 in serum, Decreased Dec 9, 2020 Dec 9, 2020 None
2092 1769: Increase, Body fluid overload 350: Increase, Mortality Apr 30, 2020 Apr 30, 2020
2741 2048: Increase, Body volume of female adults 2050: Increase, developmental abnormalities Aug 28, 2022 Aug 28, 2022
2845 2090: Bone Remodeling 2091: Bone Loss Jan 25, 2023 Aug 9, 2024
60 50: Increase, Ca++ (intracellular) 178: Disruption, Mitochondrial electron transport chain Nov 29, 2016 Dec 3, 2016
3175 2084: Increase, Cardiac remodelling 2215: Decrease LV function Apr 3, 2024 Apr 3, 2024
2103 1774: Increase, Casp transcription 1775: Increase, Oocyte apoptosis Apr 30, 2020 Apr 30, 2020
2105 1774: Increase, Casp transcription 1776: Increase, Ovarian somatic cell apoptosis Apr 30, 2020 Apr 30, 2020
2112 1779: Increase, Casp transcription (F3) 1780: Increase, Oocyte apoptosis (F3) Apr 30, 2020 Apr 30, 2020
2116 1779: Increase, Casp transcription (F3) 1783: Increase, Ovarian somatic cell apoptosis (F3) Apr 30, 2020 Apr 30, 2020
2215 1825: Increase, Cell death 1521: Decrease, Growth Dec 4, 2020 Dec 4, 2020
2467 1825: Increase, Cell death 1930: Altered, inner ear development Aug 23, 2021 Aug 29, 2021
2489 1825: Increase, Cell death 1931: Disruption of the intestinal barrier Oct 19, 2021 Oct 19, 2021 None
2706 1825: Increase, Cell death 896: Parkinsonian motor deficits Jul 25, 2022 Jul 25, 2022
2718 1825: Increase, Cell death 188: Neuroinflammation Jul 25, 2022 Jul 25, 2022 None
2760 1825: Increase, Cell death 1496: Increased proinflammatory mediators Sep 1, 2022 Sep 1, 2022
2842 1825: Increase, Cell death 2089: Altered Bone Cell Homeostasis Jan 25, 2023 Nov 6, 2024
2863 1825: Increase, Cell death 758: Hippocampal Physiology, Altered Apr 3, 2023 Apr 3, 2023 None
3504 1825: Increase, Cell death 2312: Increased, nasal lesions Mar 5, 2025 Mar 19, 2025
3507 1825: Increase, Cell death 2316: Increased, pulmonary edema Mar 12, 2025 Mar 24, 2025
3508 1825: Increase, Cell death 2317: Loss of olfactory function Mar 13, 2025 Mar 25, 2025
67 55: Cell injury/death 134: Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells) Nov 29, 2016 Nov 29, 2016 None
68 55: Cell injury/death 265: Activation, Stellate cells Nov 29, 2016 Nov 29, 2016